======= DNAJC10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNAJC10
  * **<color #00a2e8>Official Name</color>**: DnaJ heat shock protein family (Hsp40) member C10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54431|54431]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IXB1|Q8IXB1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNAJC10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNAJC10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607987|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Thioredoxin|
|DnaJ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|
|disulfide oxidoreductase activity|
|endoplasmic reticulum chaperone complex|
|protein folding in endoplasmic reticulum|
|protein disulfide oxidoreductase activity|
|ATPase activator activity|
|misfolded protein binding|
|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|
|Hsp70 protein binding|
|positive regulation of ATPase activity|
|ubiquitin-dependent ERAD pathway|
|cell redox homeostasis|
|ATPase binding|
|regulation of ATPase activity|
|ERAD pathway|
|chaperone binding|
|intrinsic apoptotic signaling pathway|
|protein folding|
|response to endoplasmic reticulum stress|
|apoptotic signaling pathway|
|endoplasmic reticulum lumen|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|cellular protein catabolic process|
|protein catabolic process|
|positive regulation of hydrolase activity|
|cellular homeostasis|
|cellular macromolecule catabolic process|
|apoptotic process|
|oxidation-reduction process|
|response to organonitrogen compound|
|endoplasmic reticulum|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|cell death|
|negative regulation of protein metabolic process|
|proteolysis|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|homeostatic process|
|intracellular signal transduction|
|cellular response to stress|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.87|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.73|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.79|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.82|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.88|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.9|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.94|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2|
|[[:results:exp73|LJH685 5μM R02 exp73]]|2.03|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.05|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13356
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNAJC10 Expression in NALM6 Cells: 7.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>