======= DNAJC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNAJC3
  * **<color #00a2e8>Official Name</color>**: DnaJ heat shock protein family (Hsp40) member C3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5611|5611]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13217|Q13217]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNAJC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNAJC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601184|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. {ECO:0000250|UniProtKB:Q27968, ECO:0000250|UniProtKB:Q91YW3, ECO:0000269|PubMed:12601012, ECO:0000269|PubMed:8576172, ECO:0000269|PubMed:9447982, ECO:0000269|PubMed:9920933}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TPR 1|
|DnaJ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of translation initiation in response to endoplasmic reticulum stress|
|positive regulation of translation in response to endoplasmic reticulum stress|
|regulation of translation initiation in response to endoplasmic reticulum stress|
|negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation|
|positive regulation of translational initiation in response to stress|
|positive regulation of translation in response to stress|
|regulation of translation in response to endoplasmic reticulum stress|
|cellular response to cold|
|regulation of translational initiation in response to stress|
|regulation of translation in response to stress|
|protein folding in endoplasmic reticulum|
|misfolded protein binding|
|smooth endoplasmic reticulum|
|protein kinase inhibitor activity|
|positive regulation of translational initiation|
|negative regulation of response to endoplasmic reticulum stress|
|response to cold|
|extracellular vesicle|
|IRE1-mediated unfolded protein response|
|regulation of translational initiation|
|regulation of response to endoplasmic reticulum stress|
|azurophil granule lumen|
|chaperone binding|
|endoplasmic reticulum unfolded protein response|
|positive regulation of translation|
|cellular response to unfolded protein|
|unfolded protein binding|
|cellular response to topologically incorrect protein|
|positive regulation of cellular amide metabolic process|
|response to unfolded protein|
|response to temperature stimulus|
|response to topologically incorrect protein|
|defense response to virus|
|negative regulation of protein kinase activity|
|protein folding|
|negative regulation of kinase activity|
|response to endoplasmic reticulum stress|
|negative regulation of transferase activity|
|response to virus|
|endoplasmic reticulum lumen|
|regulation of translation|
|post-translational protein modification|
|regulation of cellular amide metabolic process|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|protein kinase binding|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|posttranscriptional regulation of gene expression|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|myeloid leukocyte activation|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|cellular protein catabolic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|protein catabolic process|
|regulated exocytosis|
|regulation of cellular response to stress|
|leukocyte mediated immunity|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of protein kinase activity|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|leukocyte activation|
|defense response to other organism|
|regulation of transferase activity|
|negative regulation of cell death|
|secretion by cell|
|endoplasmic reticulum|
|negative regulation of cellular protein metabolic process|
|export from cell|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cell activation|
|immune effector process|
|negative regulation of protein metabolic process|
|secretion|
|negative regulation of molecular function|
|response to abiotic stimulus|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of protein modification process|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-3.72|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-3.7|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-3.64|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-3.42|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-3.37|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-3.29|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-3.26|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-3.07|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.86|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.81|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.79|
|[[:results:exp453|B02 10μM R08 exp453]]|-2.59|
|[[:results:exp218|A-395 10μM R05 exp218]]|-2.55|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-2.4|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-2.4|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.39|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-2.29|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.24|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-2.16|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2.15|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-2.05|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-2.03|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-2.01|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.01|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.01|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-1.97|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.96|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.94|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.9|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.88|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.8|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.78|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.77|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.77|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.76|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.75|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.72|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.8|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.82|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.83|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.83|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.85|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.85|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.87|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.96|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.08|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.25|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|2.32|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.37|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.62|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.67|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:manf|MANF]]|0.73|
|[[:human genes:u:ube2j1|UBE2J1]]|0.665|
|[[:human genes:d:dnajb11|DNAJB11]]|0.598|
|[[:human genes:a:alg5|ALG5]]|0.593|
|[[:human genes:d:derl1|DERL1]]|0.579|
|[[:human genes:u:ube2g2|UBE2G2]]|0.578|
|[[:human genes:d:derl2|DERL2]]|0.563|
|[[:human genes:t:tmed10|TMED10]]|0.556|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.528|
|[[:human genes:a:alg6|ALG6]]|0.517|
|[[:human genes:s:sec62|SEC62]]|0.507|
|[[:human genes:t:tmem41b|TMEM41B]]|0.505|
|[[:human genes:e:eny2|ENY2]]|0.502|
|[[:human genes:u:ufm1|UFM1]]|0.502|
|[[:human genes:v:vmp1|VMP1]]|0.502|
|[[:human genes:x:xpo6|XPO6]]|0.502|
|[[:human genes:r:rnmt|RNMT]]|0.5|
|[[:human genes:s:slc35b1|SLC35B1]]|0.496|
|[[:human genes:d:dpagt1|DPAGT1]]|0.494|
|[[:human genes:a:alg9|ALG9]]|0.493|
|[[:human genes:c:c1orf27|C1orf27]]|0.487|
|[[:human genes:t:thoc6|THOC6]]|0.485|
|[[:human genes:u:uba5|UBA5]]|0.481|
|[[:human genes:c:cbfb|CBFB]]|0.48|
|[[:human genes:d:ddx5|DDX5]]|0.478|
|[[:human genes:m:mbtps2|MBTPS2]]|0.478|
|[[:human genes:a:alg1|ALG1]]|0.476|
|[[:human genes:m:mllt1|MLLT1]]|0.475|
|[[:human genes:p:pmm2|PMM2]]|0.475|
|[[:human genes:c:ccdc101|CCDC101]]|0.475|
|[[:human genes:a:atp5o|ATP5O]]|0.474|
|[[:human genes:s:sec63|SEC63]]|0.471|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.462|
|[[:human genes:t:trmt10a|TRMT10A]]|0.46|
|[[:human genes:o:os9|OS9]]|0.46|
|[[:human genes:s:slc33a1|SLC33A1]]|0.459|
|[[:human genes:b:bap1|BAP1]]|0.452|
|[[:human genes:n:nxt1|NXT1]]|0.452|
|[[:human genes:k:kcmf1|KCMF1]]|0.452|
|[[:human genes:m:mapk14|MAPK14]]|0.451|
|[[:human genes:g:gmppb|GMPPB]]|0.451|
|[[:human genes:r:rptor|RPTOR]]|0.45|
|[[:human genes:a:atp5j|ATP5J]]|0.449|
|[[:human genes:d:dpm3|DPM3]]|0.448|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.448|
|[[:human genes:a:alg3|ALG3]]|0.445|
|[[:human genes:t:tti1|TTI1]]|0.445|
|[[:human genes:c:csnk2b|CSNK2B]]|0.44|
|[[:human genes:m:med16|MED16]]|0.439|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.438|
|[[:human genes:g:gfpt1|GFPT1]]|0.438|
|[[:human genes:n:nupl2|NUPL2]]|0.437|
|[[:human genes:f:fli1|FLI1]]|0.436|
|[[:human genes:u:ufc1|UFC1]]|0.435|
|[[:human genes:o:otud5|OTUD5]]|0.435|
|[[:human genes:u:uap1|UAP1]]|0.431|
|[[:human genes:s:srp68|SRP68]]|0.428|
|[[:human genes:d:dhx29|DHX29]]|0.427|
|[[:human genes:a:aup1|AUP1]]|0.423|
|[[:human genes:o:opa1|OPA1]]|0.42|
|[[:human genes:a:atp5a1|ATP5A1]]|0.419|
|[[:human genes:p:pdap1|PDAP1]]|0.418|
|[[:human genes:a:atp5b|ATP5B]]|0.417|
|[[:human genes:x:xpot|XPOT]]|0.416|
|[[:human genes:e:eif1|EIF1]]|0.416|
|[[:human genes:v:vcpip1|VCPIP1]]|0.416|
|[[:human genes:l:lsmd1|LSMD1]]|0.415|
|[[:human genes:a:alg8|ALG8]]|0.415|
|[[:human genes:m:med25|MED25]]|0.414|
|[[:human genes:a:atp5d|ATP5D]]|0.414|
|[[:human genes:d:dhrsx|DHRSX]]|0.413|
|[[:human genes:s:sox7|SOX7]]|0.413|
|[[:human genes:t:triap1|TRIAP1]]|0.412|
|[[:human genes:h:hsp90b1|HSP90B1]]|0.411|
|[[:human genes:h:hspd1|HSPD1]]|0.411|
|[[:human genes:h:hars|HARS]]|0.408|
|[[:human genes:m:meaf6|MEAF6]]|0.408|
|[[:human genes:a:alg2|ALG2]]|0.408|
|[[:human genes:p:polr3c|POLR3C]]|0.406|
|[[:human genes:d:dad1|DAD1]]|0.404|
|[[:human genes:t:tle4|TLE4]]|0.404|
|[[:human genes:d:dohh|DOHH]]|0.404|
|[[:human genes:a:atp2a2|ATP2A2]]|0.404|
|[[:human genes:f:faf2|FAF2]]|0.404|
|[[:human genes:s:sec16a|SEC16A]]|0.403|
|[[:human genes:d:dhdds|DHDDS]]|0.402|
|[[:human genes:d:dolk|DOLK]]|0.402|
|[[:human genes:a:alg12|ALG12]]|0.402|
|[[:human genes:a:aars|AARS]]|0.402|
|[[:human genes:i:id3|ID3]]|0.401|
|[[:human genes:w:wdr24|WDR24]]|0.401|
|[[:human genes:r:rps6kb1|RPS6KB1]]|0.401|
|[[:human genes:s:smg9|SMG9]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4356
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNAJC3 Expression in NALM6 Cells: 6.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>