======= DNAJC6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DNAJC6
  * **<color #00a2e8>Official Name</color>**: DnaJ heat shock protein family (Hsp40) member C6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9829|9829]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75061|O75061]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DNAJC6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DNAJC6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608375|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity). {ECO:0000250|UniProtKB:Q80TZ3}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PTEN C2|
|DnaJ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|synaptic vesicle uncoating|
|clathrin coat disassembly|
|vesicle uncoating|
|regulation of clathrin-dependent endocytosis|
|clathrin-dependent endocytosis|
|protein depolymerization|
|clathrin binding|
|presynaptic endocytosis|
|synaptic vesicle endocytosis|
|synaptic vesicle recycling|
|presynapse|
|regulation of receptor-mediated endocytosis|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|SH3 domain binding|
|cellular protein complex disassembly|
|vesicle|
|regulation of endocytosis|
|protein dephosphorylation|
|receptor-mediated endocytosis|
|protein-containing complex disassembly|
|postsynaptic density|
|dephosphorylation|
|cellular component disassembly|
|regulation of vesicle-mediated transport|
|endocytosis|
|import into cell|
|intracellular membrane-bounded organelle|
|membrane organization|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-2.03|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.93|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6302
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DNAJC6 Expression in NALM6 Cells: 3.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>