======= DOCK11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DOCK11
  * **<color #00a2e8>Official Name</color>**: dedicator of cytokinesis 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=139818|139818]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5JSL3|Q5JSL3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DOCK11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DOCK11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300681|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42. {ECO:0000250|UniProtKB:A2AF47}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3398|
|PH|
|Ded cyto|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|marginal zone B cell differentiation|
|mature B cell differentiation involved in immune response|
|mature B cell differentiation|
|B cell homeostasis|
|positive regulation of filopodium assembly|
|B cell activation involved in immune response|
|regulation of filopodium assembly|
|lymphocyte homeostasis|
|leukocyte homeostasis|
|Rho guanyl-nucleotide exchange factor activity|
|positive regulation of plasma membrane bounded cell projection assembly|
|guanyl-nucleotide exchange factor activity|
|B cell differentiation|
|lymphocyte activation involved in immune response|
|B cell activation|
|regulation of plasma membrane bounded cell projection assembly|
|homeostasis of number of cells|
|regulation of cell projection assembly|
|lymphocyte differentiation|
|blood coagulation|
|coagulation|
|hemostasis|
|small GTPase mediated signal transduction|
|leukocyte differentiation|
|positive regulation of cell projection organization|
|lymphocyte activation|
|positive regulation of GTPase activity|
|wound healing|
|regulation of GTPase activity|
|regulation of body fluid levels|
|positive regulation of cellular component biogenesis|
|hemopoiesis|
|response to wounding|
|hematopoietic or lymphoid organ development|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|positive regulation of hydrolase activity|
|leukocyte activation|
|regulation of cellular component biogenesis|
|cell activation|
|immune effector process|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of molecular function|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14626
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DOCK11 Expression in NALM6 Cells: 4.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>