======= DPH2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DPH2
  * **<color #00a2e8>Official Name</color>**: diphthamide biosynthesis 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1802|1802]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BQC3|Q9BQC3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DPH2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DPH2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603456|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). {ECO:0000250|UniProtKB:Q9CR25}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Diphthamide syn|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|2-(3-amino-3-carboxypropyl)histidine synthase activity|
|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|
|peptidyl-diphthamide metabolic process|
|regulation of cytoplasmic translational elongation|
|peptidyl-histidine modification|
|regulation of translational elongation|
|regulation of cytoplasmic translation|
|regulation of translation|
|regulation of cellular amide metabolic process|
|posttranscriptional regulation of gene expression|
|peptidyl-amino acid modification|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.84|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.69|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.51|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.5|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.42|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.11|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.08|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.91|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.84|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.82|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.82|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.79|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.75|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.74|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.7|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.77|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.83|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.89|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|2.51|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.76|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.99|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|3.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dph1|DPH1]]|0.726|
|[[:human genes:d:dnajc24|DNAJC24]]|0.69|
|[[:human genes:d:dph5|DPH5]]|0.685|
|[[:human genes:d:dph6|DPH6]]|0.546|
|[[:human genes:d:dph3|DPH3]]|0.483|
|[[:human genes:e:elp6|ELP6]]|0.419|
|[[:human genes:a:aar2|AAR2]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4233
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DPH2 Expression in NALM6 Cells: 6.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>