======= DPP4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DPP4
  * **<color #00a2e8>Official Name</color>**: dipeptidyl peptidase 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1803|1803]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P27487|P27487]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DPP4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DPP4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/102720|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. {ECO:0000269|PubMed:10570924, ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:10951221, ECO:0000269|PubMed:11772392, ECO:0000269|PubMed:14691230, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:17549790, ECO:0000269|PubMed:18708048}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Abhydrolase 5|
|Peptidase S9|
|Abhydrolase 6|
|DPPIV N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|psychomotor behavior|
|negative regulation of extracellular matrix disassembly|
|intercellular canaliculus|
|invadopodium membrane|
|motor behavior|
|negative regulation of extracellular matrix organization|
|regulation of cell-cell adhesion mediated by integrin|
|locomotory exploration behavior|
|dipeptidyl-peptidase activity|
|regulation of extracellular matrix disassembly|
|lamellipodium membrane|
|exploration behavior|
|behavioral fear response|
|behavioral defense response|
|fear response|
|regulation of extracellular matrix organization|
|regulation of cell adhesion mediated by integrin|
|T cell costimulation|
|lymphocyte costimulation|
|endocytic vesicle|
|serine-type peptidase activity|
|endothelial cell migration|
|multicellular organismal response to stress|
|virus receptor activity|
|epithelial cell migration|
|epithelium migration|
|tissue migration|
|viral entry into host cell|
|entry into host|
|entry into host cell|
|protease binding|
|interaction with host|
|serine-type endopeptidase activity|
|ameboidal-type cell migration|
|regulation of insulin secretion|
|lamellipodium|
|locomotory behavior|
|viral life cycle|
|positive regulation of T cell activation|
|regulation of peptide hormone secretion|
|positive regulation of leukocyte cell-cell adhesion|
|membrane raft|
|T cell activation|
|positive regulation of cell-cell adhesion|
|regulation of hormone secretion|
|regulation of leukocyte cell-cell adhesion|
|lysosomal membrane|
|regulation of T cell activation|
|apical plasma membrane|
|signaling receptor binding|
|response to hypoxia|
|response to decreased oxygen levels|
|positive regulation of lymphocyte activation|
|response to oxygen levels|
|lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|focal adhesion|
|positive regulation of cell activation|
|regulation of protein secretion|
|regulation of peptide secretion|
|regulation of lymphocyte activation|
|regulation of hormone levels|
|behavior|
|regulation of leukocyte activation|
|cell surface|
|regulation of cell activation|
|regulation of cell adhesion|
|viral process|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|protein homodimerization activity|
|positive regulation of cell population proliferation|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|cell migration|
|regulation of protein localization|
|identical protein binding|
|cell activation|
|cell motility|
|localization of cell|
|positive regulation of immune system process|
|response to abiotic stimulus|
|proteolysis|
|locomotion|
|defense response|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|regulation of immune system process|
|regulation of transport|
|extracellular region|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.436|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18518
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DPP4 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>