======= DPYSL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DPYSL2
  * **<color #00a2e8>Official Name</color>**: dihydropyrimidinase like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1808|1808]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16555|Q16555]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DPYSL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DPYSL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602463|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Amidohydro 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dihydropyrimidinase activity|
|pyrimidine nucleobase catabolic process|
|nucleobase catabolic process|
|pyrimidine nucleobase metabolic process|
|nucleobase metabolic process|
|pyrimidine-containing compound catabolic process|
|regulation of axon extension|
|pyrimidine-containing compound metabolic process|
|regulation of extent of cell growth|
|regulation of cell size|
|regulation of axonogenesis|
|microtubule binding|
|axon guidance|
|neuron projection guidance|
|regulation of cell morphogenesis involved in differentiation|
|microtubule|
|regulation of developmental growth|
|axonogenesis|
|regulation of cellular component size|
|axon development|
|regulation of cell growth|
|cell morphogenesis involved in neuron differentiation|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|organic cyclic compound catabolic process|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|cell part morphogenesis|
|nucleobase-containing small molecule metabolic process|
|chemotaxis|
|taxis|
|endocytosis|
|cell morphogenesis involved in differentiation|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|central nervous system development|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|identical protein binding|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|locomotion|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.468|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9114
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DPYSL2 Expression in NALM6 Cells: 6.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>