======= DRD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DRD1
  * **<color #00a2e8>Official Name</color>**: dopamine receptor D1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1812|1812]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21728|P21728]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DRD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DRD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/126449|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srsx|
|7TM GPCR Srx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sensitization|
|dopamine neurotransmitter receptor activity, coupled via Gs|
|dopamine neurotransmitter receptor activity|
|operant conditioning|
|habituation|
|histone H3-S10 phosphorylation|
|conditioned taste aversion|
|nonassociative learning|
|interneuron migration|
|cerebral cortex GABAergic interneuron migration|
|cerebral cortex GABAergic interneuron development|
|phospholipase C-activating dopamine receptor signaling pathway|
|glucose import|
|regulation of catecholamine uptake involved in synaptic transmission|
|regulation of dopamine uptake involved in synaptic transmission|
|interneuron migration from the subpallium to the cortex|
|peristalsis|
|adenylate cyclase-activating dopamine receptor signaling pathway|
|histone-serine phosphorylation|
|dopamine transport|
|cerebral cortex GABAergic interneuron differentiation|
|substrate-independent telencephalic tangential migration|
|substrate-independent telencephalic tangential interneuron migration|
|parental behavior|
|maternal behavior|
|dopamine binding|
|catecholamine transport|
|grooming behavior|
|GABAergic neuron differentiation|
|prepulse inhibition|
|regulation of synaptic transmission, dopaminergic|
|dentate gyrus development|
|long-term synaptic depression|
|phasic smooth muscle contraction|
|striatum development|
|synaptic transmission, dopaminergic|
|regulation of neurotransmitter uptake|
|regulation of catecholamine metabolic process|
|regulation of dopamine metabolic process|
|behavioral response to cocaine|
|mating behavior|
|monoamine transport|
|cerebral cortex neuron differentiation|
|subpallium development|
|G-protein alpha-subunit binding|
|startle response|
|dopamine metabolic process|
|reproductive behavior|
|neuronal action potential|
|histone phosphorylation|
|adult walking behavior|
|behavioral fear response|
|vasodilation|
|temperature homeostasis|
|forebrain neuron development|
|walking behavior|
|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|
|behavioral defense response|
|positive regulation of synaptic transmission, glutamatergic|
|response to amphetamine|
|non-motile cilium|
|glucose transmembrane transport|
|mating|
|fear response|
|dopamine receptor signaling pathway|
|hexose transmembrane transport|
|astrocyte development|
|monosaccharide transmembrane transport|
|carbohydrate transmembrane transport|
|activation of adenylate cyclase activity|
|positive regulation of release of sequestered calcium ion into cytosol|
|catecholamine metabolic process|
|catechol-containing compound metabolic process|
|integral component of postsynaptic membrane|
|positive regulation of potassium ion transport|
|response to amine|
|long-term synaptic potentiation|
|visual learning|
|response to bronchodilator|
|forebrain neuron differentiation|
|ammonium transport|
|smooth muscle contraction|
|astrocyte differentiation|
|visual behavior|
|ciliary membrane|
|positive regulation of calcium ion transport into cytosol|
|response to cocaine|
|transmission of nerve impulse|
|positive regulation of blood vessel diameter|
|telencephalon cell migration|
|integral component of presynaptic membrane|
|forebrain cell migration|
|negative regulation of synaptic transmission|
|forebrain generation of neurons|
|GABA-ergic synapse|
|multicellular organismal response to stress|
|regulation of synaptic transmission, glutamatergic|
|positive regulation of calcium ion transmembrane transport|
|carbohydrate transport|
|adult locomotory behavior|
|regulation of release of sequestered calcium ion into cytosol|
|associative learning|
|response to anesthetic|
|regulation of synaptic vesicle exocytosis|
|regulation of cellular amine metabolic process|
|central nervous system neuron development|
|hippocampus development|
|phenol-containing compound metabolic process|
|cellular response to dopamine|
|feeding behavior|
|response to dopamine|
|signal transduction involved in cellular response to ammonium ion|
|synapse assembly|
|regulation of amine transport|
|action potential|
|protein import into nucleus|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of potassium ion transport|
|regulation of calcium ion transport into cytosol|
|regulation of response to drug|
|cellular response to catecholamine stimulus|
|cellular response to monoamine stimulus|
|regulation of neurotransmitter secretion|
|response to catecholamine|
|response to monoamine|
|glial cell development|
|neuromuscular process|
|limbic system development|
|regulation of synaptic vesicle cycle|
|response to alkaloid|
|import into nucleus|
|memory|
|neuron migration|
|positive regulation of calcium ion transport|
|regulation of sequestering of calcium ion|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|cellular response to ammonium ion|
|multicellular organismal signaling|
|organic hydroxy compound transport|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|protein import|
|positive regulation of cation transmembrane transport|
|regulation of neurotransmitter transport|
|adult behavior|
|learning|
|cAMP-mediated signaling|
|regulation of calcium ion transmembrane transport|
|drug transport|
|dendritic spine|
|positive regulation of synaptic transmission|
|positive regulation of ion transmembrane transport|
|protein localization to nucleus|
|regulation of regulated secretory pathway|
|vascular process in circulatory system|
|glial cell differentiation|
|cyclic-nucleotide-mediated signaling|
|pallium development|
|peptidyl-serine phosphorylation|
|central nervous system neuron differentiation|
|response to ammonium ion|
|regulation of synaptic plasticity|
|ammonium ion metabolic process|
|locomotory behavior|
|peptidyl-serine modification|
|cilium|
|positive regulation of transmembrane transport|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|gliogenesis|
|regulation of exocytosis|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of calcium ion transport|
|muscle contraction|
|telencephalon development|
|learning or memory|
|nucleocytoplasmic transport|
|nuclear transport|
|synapse organization|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|cognition|
|muscle system process|
|response to xenobiotic stimulus|
|response to light stimulus|
|multicellular organismal homeostasis|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|histone modification|
|negative regulation of response to external stimulus|
|covalent chromatin modification|
|forebrain development|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|cellular response to drug|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|regulation of membrane potential|
|establishment of protein localization to organelle|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|organic hydroxy compound metabolic process|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|divalent inorganic cation homeostasis|
|drug metabolic process|
|positive regulation of cell migration|
|response to toxic substance|
|regulation of anatomical structure size|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|cellular response to organic cyclic compound|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|behavior|
|cellular response to organonitrogen compound|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cellular response to nitrogen compound|
|chromatin organization|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|protein localization to organelle|
|brain development|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|head development|
|ion homeostasis|
|regulation of secretion|
|neuron development|
|multicellular organismal reproductive process|
|cation transport|
|sexual reproduction|
|multicellular organism reproduction|
|regulation of cell migration|
|peptidyl-amino acid modification|
|cellular homeostasis|
|regulation of cell motility|
|regulation of cellular localization|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|cell migration|
|protein phosphorylation|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|multi-organism reproductive process|
|regulation of cellular component movement|
|intracellular protein transport|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|cellular response to oxygen-containing compound|
|chromosome organization|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|regulation of response to external stimulus|
|chemical homeostasis|
|cell-cell signaling|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|transmembrane transport|
|phosphorylation|
|locomotion|
|G protein-coupled receptor signaling pathway|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|cell development|
|intracellular signal transduction|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.72|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10276
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DRD1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>