======= DRD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DRD2
  * **<color #00a2e8>Official Name</color>**: dopamine receptor D2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1813|1813]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14416|P14416]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DRD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DRD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/126450|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. {ECO:0000269|PubMed:21645528}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7TM GPCR Srx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of glial cell-derived neurotrophic factor secretion|
|regulation of glial cell-derived neurotrophic factor secretion|
|negative regulation of dopamine secretion|
|positive regulation of dopamine uptake involved in synaptic transmission|
|positive regulation of catecholamine uptake involved in synaptic transmission|
|orbitofrontal cortex development|
|negative regulation of dopamine receptor signaling pathway|
|branching morphogenesis of a nerve|
|negative regulation of circadian sleep/wake cycle, sleep|
|positive regulation of neurotransmitter uptake|
|regulation of locomotion involved in locomotory behavior|
|interneuron migration|
|cerebral cortex GABAergic interneuron migration|
|phospholipase C-activating dopamine receptor signaling pathway|
|positive regulation of synaptic transmission, dopaminergic|
|regulation of synapse structural plasticity|
|cerebral cortex GABAergic interneuron development|
|dopamine neurotransmitter receptor activity, coupled via Gi/Go|
|regulation of catecholamine uptake involved in synaptic transmission|
|neuron-neuron synaptic transmission|
|regulation of dopamine uptake involved in synaptic transmission|
|positive regulation of growth hormone secretion|
|negative regulation of synaptic transmission, glutamatergic|
|interneuron migration from the subpallium to the cortex|
|drinking behavior|
|adenylate cyclase-inhibiting dopamine receptor signaling pathway|
|behavioral response to ethanol|
|peristalsis|
|response to histamine|
|nervous system process involved in regulation of systemic arterial blood pressure|
|cerebral cortex GABAergic interneuron differentiation|
|regulation of dopamine receptor signaling pathway|
|substrate-independent telencephalic tangential migration|
|substrate-independent telencephalic tangential interneuron migration|
|negative regulation of cytosolic calcium ion concentration|
|adenohypophysis development|
|auditory behavior|
|dopaminergic synapse|
|G protein-coupled receptor internalization|
|dopamine binding|
|regulation of growth hormone secretion|
|negative regulation of voltage-gated calcium channel activity|
|grooming behavior|
|positive regulation of urine volume|
|positive regulation of renal sodium excretion|
|response to inactivity|
|GABAergic neuron differentiation|
|negative regulation of circadian rhythm|
|negative regulation of catecholamine secretion|
|prepulse inhibition|
|mechanosensory behavior|
|regulation of synaptic transmission, dopaminergic|
|postsynaptic modulation of chemical synaptic transmission|
|regulation of circadian sleep/wake cycle, sleep|
|adrenergic receptor activity|
|negative regulation of behavior|
|phasic smooth muscle contraction|
|striatum development|
|negative adaptation of signaling pathway|
|synaptic transmission, dopaminergic|
|desensitization of G protein-coupled receptor signaling pathway|
|regulation of neurotransmitter uptake|
|adaptation of signaling pathway|
|negative regulation of cellular response to drug|
|behavioral response to cocaine|
|positive regulation of long-term synaptic potentiation|
|regulation of renal sodium excretion|
|regulation of circadian sleep/wake cycle|
|regulation of urine volume|
|positive regulation of neuroblast proliferation|
|adrenergic receptor signaling pathway|
|adenylate cyclase-activating adrenergic receptor signaling pathway|
|arachidonate transport|
|regulation of excretion|
|arachidonic acid secretion|
|cerebral cortex neuron differentiation|
|subpallium development|
|positive regulation of receptor internalization|
|negative regulation of amine transport|
|response to auditory stimulus|
|icosanoid secretion|
|startle response|
|regulation of long-term neuronal synaptic plasticity|
|positive regulation of G protein-coupled receptor signaling pathway|
|negative regulation of response to drug|
|dopamine metabolic process|
|adult walking behavior|
|temperature homeostasis|
|forebrain neuron development|
|walking behavior|
|icosanoid transport|
|fatty acid derivative transport|
|positive regulation of multicellular organism growth|
|positive regulation of response to drug|
|non-motile cilium|
|regulation of synaptic transmission, GABAergic|
|long-term memory|
|response to amphetamine|
|regulation of neuroblast proliferation|
|response to isoquinoline alkaloid|
|ionotropic glutamate receptor binding|
|response to morphine|
|response to iron ion|
|regulation of renal system process|
|regulation of voltage-gated calcium channel activity|
|dopamine receptor signaling pathway|
|negative regulation of calcium ion transmembrane transporter activity|
|regulation of cellular response to drug|
|positive regulation of amine transport|
|positive regulation of neurotransmitter transport|
|negative regulation of insulin secretion|
|positive regulation of stem cell proliferation|
|positive regulation of cytokinesis|
|negative regulation of calcium ion transmembrane transport|
|regulation of dopamine secretion|
|pituitary gland development|
|negative regulation of cation channel activity|
|catecholamine metabolic process|
|sperm flagellum|
|catechol-containing compound metabolic process|
|regulation of long-term synaptic potentiation|
|integral component of postsynaptic membrane|
|negative regulation of peptide hormone secretion|
|negative regulation of blood pressure|
|response to amine|
|negative regulation of protein kinase B signaling|
|negative regulation of G protein-coupled receptor signaling pathway|
|visual learning|
|response to axon injury|
|response to nicotine|
|forebrain neuron differentiation|
|response to bronchodilator|
|positive regulation of neural precursor cell proliferation|
|positive regulation of receptor-mediated endocytosis|
|smooth muscle contraction|
|axon terminus|
|regulation of neuronal synaptic plasticity|
|visual behavior|
|ciliary membrane|
|regulation of receptor internalization|
|response to cocaine|
|release of sequestered calcium ion into cytosol|
|negative regulation of innate immune response|
|lateral plasma membrane|
|drug binding|
|negative regulation of sequestering of calcium ion|
|telencephalon cell migration|
|endocytic vesicle|
|long-chain fatty acid transport|
|integral component of presynaptic membrane|
|negative regulation of calcium ion transport|
|negative regulation of synaptic transmission|
|forebrain cell migration|
|regulation of catecholamine secretion|
|circadian regulation of gene expression|
|receptor internalization|
|negative regulation of hormone secretion|
|excitatory postsynaptic potential|
|regulation of stem cell proliferation|
|regulation of multicellular organism growth|
|forebrain generation of neurons|
|calcium ion transmembrane import into cytosol|
|chemical synaptic transmission, postsynaptic|
|GABA-ergic synapse|
|synaptic vesicle membrane|
|regulation of synaptic transmission, glutamatergic|
|negative regulation of ion transmembrane transporter activity|
|regulation of behavior|
|fatty acid transport|
|calcium ion transport into cytosol|
|diencephalon development|
|adult locomotory behavior|
|associative learning|
|response to anesthetic|
|regulation of synaptic vesicle exocytosis|
|negative regulation of transporter activity|
|acid secretion|
|central nervous system neuron development|
|negative regulation of cation transmembrane transport|
|phenol-containing compound metabolic process|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|cellular response to dopamine|
|feeding behavior|
|positive regulation of cell division|
|response to dopamine|
|acrosomal vesicle|
|regulation of sodium ion transport|
|regulation of neural precursor cell proliferation|
|regulation of calcium ion transmembrane transporter activity|
|cytosolic calcium ion transport|
|regulation of cytokinesis|
|pigmentation|
|negative regulation of response to biotic stimulus|
|signal transduction involved in cellular response to ammonium ion|
|synapse assembly|
|regulation of amine transport|
|regulation of systemic arterial blood pressure|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|negative regulation of ion transmembrane transport|
|regulation of potassium ion transport|
|regulation of heart rate|
|positive regulation of peptide hormone secretion|
|regulation of response to drug|
|regulation of receptor-mediated endocytosis|
|positive regulation of endocytosis|
|regulation of postsynaptic membrane potential|
|cellular response to catecholamine stimulus|
|cellular response to monoamine stimulus|
|regulation of neurotransmitter secretion|
|receptor metabolic process|
|response to catecholamine|
|response to monoamine|
|neuromuscular process|
|limbic system development|
|renal system process|
|response to alkaloid|
|regulation of synaptic vesicle cycle|
|regulation of circadian rhythm|
|negative regulation of transmembrane transport|
|regulation of phosphoprotein phosphatase activity|
|memory|
|neuron migration|
|endocrine system development|
|regulation of sequestering of calcium ion|
|response to ethanol|
|positive regulation of hormone secretion|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|cellular response to ammonium ion|
|negative regulation of protein secretion|
|perikaryon|
|monocarboxylic acid transport|
|negative regulation of peptide secretion|
|positive regulation of cytokine secretion|
|regulation of protein dephosphorylation|
|circadian rhythm|
|regulation of G protein-coupled receptor signaling pathway|
|regulation of neurotransmitter transport|
|adult behavior|
|learning|
|cAMP-mediated signaling|
|negative regulation of ion transport|
|regulation of calcium ion transmembrane transport|
|negative regulation of immune response|
|dendritic spine|
|positive regulation of synaptic transmission|
|regulation of regulated secretory pathway|
|morphogenesis of a branching structure|
|regulation of cell division|
|positive regulation of developmental growth|
|cyclic-nucleotide-mediated signaling|
|regulation of cation channel activity|
|regulation of phosphatase activity|
|regulation of insulin secretion|
|central nervous system neuron differentiation|
|negative regulation of protein transport|
|regulation of blood pressure|
|response to ammonium ion|
|negative regulation of establishment of protein localization|
|regulation of synaptic plasticity|
|ammonium ion metabolic process|
|locomotory behavior|
|calcium ion transmembrane transport|
|cilium|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of endocytosis|
|negative regulation of defense response|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of peptide hormone secretion|
|regulation of dephosphorylation|
|positive regulation of ERK1 and ERK2 cascade|
|response to mechanical stimulus|
|negative regulation of multi-organism process|
|regulation of synapse organization|
|regulation of protein kinase B signaling|
|regulation of exocytosis|
|regulation of synapse structure or activity|
|negative regulation of secretion|
|response to alcohol|
|receptor-mediated endocytosis|
|regulation of heart contraction|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of calcium ion transport|
|calcium ion transport|
|muscle contraction|
|postsynaptic density|
|telencephalon development|
|regulation of ion transmembrane transporter activity|
|negative regulation of cell migration|
|learning or memory|
|positive regulation of growth|
|autophagy|
|process utilizing autophagic mechanism|
|regulation of transmembrane transporter activity|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|synapse organization|
|negative regulation of cell motility|
|positive regulation of ion transport|
|rhythmic process|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|positive regulation of cell cycle process|
|regulation of blood circulation|
|positive regulation of peptide secretion|
|organic acid transport|
|carboxylic acid transport|
|regulation of ERK1 and ERK2 cascade|
|axon|
|divalent metal ion transport|
|lipid transport|
|cognition|
|muscle system process|
|response to xenobiotic stimulus|
|divalent inorganic cation transport|
|response to antibiotic|
|response to light stimulus|
|negative regulation of cellular component movement|
|lipid localization|
|negative regulation of locomotion|
|multicellular organismal homeostasis|
|regulation of cytosolic calcium ion concentration|
|activation of protein kinase activity|
|regulation of developmental growth|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|response to hypoxia|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|cell-cell signaling by wnt|
|response to decreased oxygen levels|
|Wnt signaling pathway|
|negative regulation of response to external stimulus|
|response to metal ion|
|axonogenesis|
|positive regulation of cell cycle|
|response to oxygen levels|
|forebrain development|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|cellular response to drug|
|positive regulation of secretion by cell|
|negative regulation of protein phosphorylation|
|axon development|
|gland development|
|dendrite|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|positive regulation of protein transport|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|response to radiation|
|negative regulation of immune system process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of phosphorylation|
|calcium ion homeostasis|
|positive regulation of cytokine production|
|regulation of innate immune response|
|organic hydroxy compound metabolic process|
|organic anion transport|
|positive regulation of establishment of protein localization|
|synaptic signaling|
|sensory perception of smell|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|regulation of ion transmembrane transport|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|negative regulation of transport|
|protein heterodimerization activity|
|divalent inorganic cation homeostasis|
|cell projection morphogenesis|
|regulation of peptide secretion|
|regulation of body fluid levels|
|drug metabolic process|
|negative regulation of intracellular signal transduction|
|response to toxic substance|
|cell part morphogenesis|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|regulation of hormone levels|
|response to inorganic substance|
|positive regulation of nervous system development|
|sensory perception of chemical stimulus|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|endocytosis|
|cell morphogenesis involved in differentiation|
|cellular metal ion homeostasis|
|negative regulation of phosphate metabolic process|
|inorganic cation transmembrane transport|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|response to wounding|
|behavior|
|positive regulation of kinase activity|
|anion transport|
|regulation of system process|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|neuron projection development|
|regulation of growth|
|import into cell|
|negative regulation of cell population proliferation|
|regulation of cytokine production|
|regulation of ion transport|
|cation homeostasis|
|regulation of protein transport|
|inorganic ion homeostasis|
|cell morphogenesis|
|regulation of peptide transport|
|brain development|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of multi-organism process|
|head development|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|cation transport|
|regulation of cell migration|
|regulation of kinase activity|
|protein homodimerization activity|
|cellular homeostasis|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|ion transmembrane transport|
|cell migration|
|positive regulation of cell differentiation|
|sensory perception|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of cellular component movement|
|response to organonitrogen compound|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|identical protein binding|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|cell projection organization|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|transmembrane transport|
|locomotion|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.42|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.01|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4269
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DRD2 Expression in NALM6 Cells: -4.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>