======= DRG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DRG1
  * **<color #00a2e8>Official Name</color>**: developmentally regulated GTP binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4733|4733]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y295|Q9Y295]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DRG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DRG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603952|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TGS|
|FeoB N|
|MMR HSR1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|potassium ion binding|
|regulation of mitotic spindle assembly|
|regulation of spindle assembly|
|positive regulation of microtubule polymerization|
|positive regulation of microtubule polymerization or depolymerization|
|regulation of mitotic spindle organization|
|regulation of spindle organization|
|polysome|
|regulation of microtubule polymerization|
|cytoplasmic translation|
|regulation of microtubule polymerization or depolymerization|
|positive regulation of protein polymerization|
|regulation of mitotic nuclear division|
|regulation of microtubule cytoskeleton organization|
|regulation of nuclear division|
|positive regulation of supramolecular fiber organization|
|regulation of organelle assembly|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|microtubule binding|
|positive regulation of protein complex assembly|
|nuclear body|
|GTPase activity|
|transcription factor binding|
|regulation of supramolecular fiber organization|
|translation|
|GTP binding|
|peptide biosynthetic process|
|regulation of protein complex assembly|
|positive regulation of cellular component biogenesis|
|amide biosynthetic process|
|peptide metabolic process|
|regulation of cytoskeleton organization|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of cell cycle process|
|cellular amide metabolic process|
|regulation of cellular component biogenesis|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.82|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.23|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.85|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.77|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.7|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.7|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.74|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.74|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.76|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.81|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.84|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.87|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.91|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.94|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.94|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.97|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.14|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.33|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.46|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.75|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.79|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.87|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.95|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|3.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zc3h15|ZC3H15]]|0.487|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7823
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DRG1 Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>