======= DTX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DTX1
  * **<color #00a2e8>Official Name</color>**: deltex E3 ubiquitin ligase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1840|1840]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86Y01|Q86Y01]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DTX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DTX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602582|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T- cell development, suggesting that it can antagonize NOTCH1. {ECO:0000250, ECO:0000269|PubMed:11564735, ECO:0000269|PubMed:11869684, ECO:0000269|PubMed:9590294}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WWE|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Notch binding|
|negative regulation of T cell differentiation|
|negative regulation of lymphocyte differentiation|
|transferase activity|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|negative regulation of leukocyte differentiation|
|regulation of Notch signaling pathway|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|Notch signaling pathway|
|SH3 domain binding|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|negative regulation of lymphocyte activation|
|regulation of lymphocyte differentiation|
|glial cell differentiation|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|negative regulation of cell activation|
|gliogenesis|
|negative regulation of neuron differentiation|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|nuclear body|
|transcription coactivator activity|
|negative regulation of neurogenesis|
|ubiquitin protein ligase binding|
|regulation of leukocyte cell-cell adhesion|
|negative regulation of nervous system development|
|regulation of T cell activation|
|negative regulation of cell development|
|regulation of cell-cell adhesion|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|transcription by RNA polymerase II|
|regulation of lymphocyte activation|
|regulation of leukocyte activation|
|transcription, DNA-templated|
|regulation of cell activation|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of neuron differentiation|
|regulation of cell adhesion|
|protein ubiquitination|
|negative regulation of cell differentiation|
|protein modification by small protein conjugation|
|regulation of neurogenesis|
|zinc ion binding|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|protein modification by small protein conjugation or removal|
|cellular response to cytokine stimulus|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|organic cyclic compound biosynthetic process|
|generation of neurons|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9872
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DTX1 Expression in NALM6 Cells: 7.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>