======= DTX3L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DTX3L
  * **<color #00a2e8>Official Name</color>**: deltex E3 ubiquitin ligase 3L
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=151636|151636]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TDB6|Q8TDB6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DTX3L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DTX3L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613143|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:26479788, PubMed:23230272). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). By monoubiquitinating histone H2B HIST1H2BH/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon- stimulated gene transcription and thus STAT1-mediated control of viral replication (PubMed:26479788). Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM (PubMed:24790097). In addition, required for the recruitment of HGS and STAM to early endosomes (PubMed:24790097). In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteosomal-mediated degradation (PubMed:26479788). {ECO:0000269|PubMed:12670957, ECO:0000269|PubMed:19818714, ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28525742}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C3HC4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of NAD+ ADP-ribosyltransferase activity|
|positive regulation of NAD+ ADP-ribosyltransferase activity|
|positive regulation of receptor catabolic process|
|regulation of protein localization to early endosome|
|positive regulation of protein localization to early endosome|
|STAT family protein binding|
|regulation of receptor catabolic process|
|histone H2B ubiquitination|
|positive regulation of protein localization to endosome|
|regulation of protein localization to endosome|
|positive regulation of chromatin binding|
|positive regulation of double-strand break repair via nonhomologous end joining|
|negative regulation of ubiquitin-protein transferase activity|
|regulation of chromatin binding|
|ubiquitin-like protein ligase binding|
|histone H2A ubiquitination|
|regulation of double-strand break repair via nonhomologous end joining|
|positive regulation of defense response to virus by host|
|histone monoubiquitination|
|positive regulation of double-strand break repair|
|enzyme inhibitor activity|
|regulation of defense response to virus by host|
|histone ubiquitination|
|enzyme activator activity|
|regulation of ubiquitin-protein transferase activity|
|protein K48-linked ubiquitination|
|endosome to lysosome transport|
|protein monoubiquitination|
|protein autoubiquitination|
|positive regulation of DNA repair|
|negative regulation of protein ubiquitination|
|regulation of defense response to virus|
|positive regulation of protein localization to nucleus|
|regulation of double-strand break repair|
|negative regulation of protein modification by small protein conjugation or removal|
|positive regulation of protein binding|
|positive regulation of response to DNA damage stimulus|
|lysosomal transport|
|regulation of protein localization to nucleus|
|regulation of DNA repair|
|Notch signaling pathway|
|histone binding|
|vacuolar transport|
|early endosome membrane|
|positive regulation of binding|
|double-strand break repair|
|defense response to virus|
|positive regulation of DNA metabolic process|
|regulation of protein ubiquitination|
|regulation of response to DNA damage stimulus|
|regulation of protein binding|
|regulation of protein modification by small protein conjugation or removal|
|ubiquitin-protein transferase activity|
|lysosome|
|early endosome|
|negative regulation of transferase activity|
|response to virus|
|protein polyubiquitination|
|lysosomal membrane|
|positive regulation of cellular protein localization|
|enzyme binding|
|regulation of DNA metabolic process|
|histone modification|
|positive regulation of cellular catabolic process|
|covalent chromatin modification|
|regulation of binding|
|positive regulation of catabolic process|
|regulation of immune effector process|
|DNA repair|
|regulation of response to biotic stimulus|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cellular protein localization|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|protein-containing complex|
|cellular protein catabolic process|
|positive regulation of transferase activity|
|protein catabolic process|
|protein ubiquitination|
|chromatin organization|
|regulation of cellular response to stress|
|DNA metabolic process|
|regulation of defense response|
|innate immune response|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|defense response to other organism|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|immune effector process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|amide transport|
|establishment of protein localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.84|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.78|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.72|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|2.06|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.67|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17618
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DTX3L Expression in NALM6 Cells: 6.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>