======= DUOX2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DUOX2
  * **<color #00a2e8>Official Name</color>**: dual oxidase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=50506|50506]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NRD8|Q9NRD8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DUOX2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DUOX2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606759|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. {ECO:0000269|PubMed:12824283}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|An peroxidase|
|FAD binding 8|
|Ferric reduct|
|NAD binding 6|
|efhand|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cuticle development|
|NAD(P)H oxidase activity|
|hydrogen peroxide biosynthetic process|
|superoxide-generating NADPH oxidase activity|
|thyroid hormone generation|
|antibiotic biosynthetic process|
|NADPH oxidase complex|
|superoxide anion generation|
|thyroid hormone metabolic process|
|reactive oxygen species biosynthetic process|
|hydrogen peroxide catabolic process|
|peroxidase activity|
|hydrogen peroxide metabolic process|
|superoxide metabolic process|
|cell leading edge|
|antibiotic catabolic process|
|positive regulation of wound healing|
|cofactor catabolic process|
|hormone biosynthetic process|
|positive regulation of response to wounding|
|apical part of cell|
|phenol-containing compound metabolic process|
|cellular oxidant detoxification|
|response to cAMP|
|cellular detoxification|
|antibiotic metabolic process|
|reactive oxygen species metabolic process|
|detoxification|
|response to organophosphorus|
|regulation of wound healing|
|heme binding|
|drug catabolic process|
|response to purine-containing compound|
|regulation of response to wounding|
|cellular modified amino acid metabolic process|
|hormone metabolic process|
|cofactor biosynthetic process|
|cellular response to toxic substance|
|response to virus|
|apical plasma membrane|
|response to oxidative stress|
|cofactor metabolic process|
|organic hydroxy compound metabolic process|
|drug metabolic process|
|response to toxic substance|
|positive regulation of cell motility|
|regulation of hormone levels|
|positive regulation of cellular component movement|
|cell junction|
|positive regulation of locomotion|
|cell surface|
|cytokine-mediated signaling pathway|
|calcium ion binding|
|regulation of cell motility|
|response to organic cyclic compound|
|oxidation-reduction process|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|response to nitrogen compound|
|response to cytokine|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|response to oxygen-containing compound|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.99|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.94|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.88|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.87|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.82|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.81|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.77|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14302
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.5 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DUOX2 Expression in NALM6 Cells: 1.5'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>