======= DUS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DUS2
  * **<color #00a2e8>Official Name</color>**: dihydrouridine synthase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54920|54920]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NX74|Q9NX74]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DUS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DUS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609707|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. {ECO:0000269|PubMed:15994936, ECO:0000269|PubMed:18096616}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Dus|
|dsrm|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA-dihydrouridine20 synthase activity|
|tRNA dihydrouridine synthesis|
|tRNA dihydrouridine synthase activity|
|NADPH binding|
|FMN binding|
|protein kinase inhibitor activity|
|flavin adenine dinucleotide binding|
|double-stranded RNA binding|
|tRNA modification|
|tRNA processing|
|RNA modification|
|tRNA metabolic process|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|negative regulation of transferase activity|
|ncRNA processing|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|ncRNA metabolic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|RNA processing|
|oxidation-reduction process|
|regulation of transferase activity|
|negative regulation of cell death|
|endoplasmic reticulum|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|RNA metabolic process|
|regulation of cell death|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-2.1|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-2|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.92|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.82|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.78|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.73|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6816
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DUS2 Expression in NALM6 Cells: 4.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>