======= DUSP4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DUSP4
  * **<color #00a2e8>Official Name</color>**: dual specificity phosphatase 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1846|1846]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13115|Q13115]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DUSP4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DUSP4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602747|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. {ECO:0000269|PubMed:7535768}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rhodanese|
|DSPc|
|Y phosphatase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|MAP kinase serine/threonine phosphatase activity|
|protein tyrosine/threonine phosphatase activity|
|MAP kinase tyrosine/serine/threonine phosphatase activity|
|peptidyl-threonine dephosphorylation|
|inactivation of MAPK activity|
|protein tyrosine/serine/threonine phosphatase activity|
|phosphatase activity|
|negative regulation of ERK1 and ERK2 cascade|
|negative regulation of MAP kinase activity|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|negative regulation of protein serine/threonine kinase activity|
|negative regulation of MAPK cascade|
|protein dephosphorylation|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|negative regulation of transferase activity|
|regulation of ERK1 and ERK2 cascade|
|dephosphorylation|
|regulation of MAP kinase activity|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|regulation of transferase activity|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 13/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11392
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.66 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DUSP4 Expression in NALM6 Cells: 0.66'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>