======= DUT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DUT
  * **<color #00a2e8>Official Name</color>**: deoxyuridine triphosphatase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1854|1854]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P33316|P33316]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DUT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DUT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601266|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|dUTPase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dUTP catabolic process|
|dUTP diphosphatase activity|
|dUTP metabolic process|
|pyrimidine nucleoside triphosphate catabolic process|
|pyrimidine deoxyribonucleoside triphosphate catabolic process|
|dUMP biosynthetic process|
|dUMP metabolic process|
|pyrimidine deoxyribonucleoside monophosphate biosynthetic process|
|pyrimidine deoxyribonucleoside triphosphate metabolic process|
|pyrimidine deoxyribonucleoside monophosphate metabolic process|
|deoxyribonucleoside triphosphate catabolic process|
|pyrimidine deoxyribonucleotide biosynthetic process|
|deoxyribonucleoside monophosphate biosynthetic process|
|2-deoxyribonucleotide biosynthetic process|
|deoxyribose phosphate biosynthetic process|
|deoxyribonucleoside monophosphate metabolic process|
|nucleoside triphosphate catabolic process|
|pyrimidine deoxyribonucleotide catabolic process|
|pyrimidine nucleotide catabolic process|
|deoxyribonucleotide biosynthetic process|
|pyrimidine nucleoside monophosphate biosynthetic process|
|pyrimidine nucleoside monophosphate metabolic process|
|deoxyribonucleoside triphosphate metabolic process|
|deoxyribonucleotide catabolic process|
|pyrimidine deoxyribonucleotide metabolic process|
|deoxyribose phosphate catabolic process|
|pyrimidine nucleoside triphosphate metabolic process|
|nucleobase-containing small molecule interconversion|
|2-deoxyribonucleotide metabolic process|
|deoxyribose phosphate metabolic process|
|deoxyribonucleotide metabolic process|
|pyrimidine-containing compound catabolic process|
|nucleoside monophosphate biosynthetic process|
|pyrimidine nucleotide biosynthetic process|
|pyrimidine-containing compound biosynthetic process|
|pyrimidine nucleotide metabolic process|
|nucleotide catabolic process|
|nucleoside phosphate catabolic process|
|nucleoside monophosphate metabolic process|
|nucleoside triphosphate metabolic process|
|nucleobase-containing small molecule biosynthetic process|
|pyrimidine-containing compound metabolic process|
|organophosphate catabolic process|
|carbohydrate derivative catabolic process|
|DNA replication|
|magnesium ion binding|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic cyclic compound catabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 729/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|28/28|
|blood|28/28|
|bone|24/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4607
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DUT Expression in NALM6 Cells: 7.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>