======= EBNA1BP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EBNA1BP2
  * **<color #00a2e8>Official Name</color>**: EBNA1 binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10969|10969]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99848|Q99848]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EBNA1BP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EBNA1BP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614443|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the processing of the 27S pre-rRNA. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ebp2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear periphery|
|preribosome, large subunit precursor|
|ribosomal large subunit biogenesis|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-2.04|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.85|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.74|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.8|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.83|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.92|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|1.92|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.562|
|[[:human genes:r:rpl35|RPL35]]|0.527|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.495|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.492|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.481|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.478|
|[[:human genes:r:rrp7a|RRP7A]]|0.476|
|[[:human genes:t:tceb3c|TCEB3C]]|0.474|
|[[:human genes:c:chd4|CHD4]]|0.468|
|[[:human genes:c:c14orf93|C14orf93]]|0.468|
|[[:human genes:k:kctd17|KCTD17]]|0.467|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.466|
|[[:human genes:r:rrn3|RRN3]]|0.465|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.462|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.46|
|[[:human genes:g:golga8r|GOLGA8R]]|0.46|
|[[:human genes:d:disp2|DISP2]]|0.458|
|[[:human genes:u:utp3|UTP3]]|0.456|
|[[:human genes:n:nol10|NOL10]]|0.452|
|[[:human genes:p:polr2j3|POLR2J3]]|0.452|
|[[:human genes:p:psmd2|PSMD2]]|0.451|
|[[:human genes:r:rps19|RPS19]]|0.451|
|[[:human genes:r:rplp0|RPLP0]]|0.45|
|[[:human genes:r:rnpc3|RNPC3]]|0.448|
|[[:human genes:p:pole|POLE]]|0.448|
|[[:human genes:r:rps5|RPS5]]|0.448|
|[[:human genes:r:rps12|RPS12]]|0.448|
|[[:human genes:e:exosc9|EXOSC9]]|0.447|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.446|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.445|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.444|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.441|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.441|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.441|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.441|
|[[:human genes:p:psmb4|PSMB4]]|0.44|
|[[:human genes:r:rbbp5|RBBP5]]|0.44|
|[[:human genes:p:psmb2|PSMB2]]|0.439|
|[[:human genes:n:nol7|NOL7]]|0.439|
|[[:human genes:u:utp20|UTP20]]|0.436|
|[[:human genes:d:dtl|DTL]]|0.435|
|[[:human genes:r:rpl6|RPL6]]|0.434|
|[[:human genes:p:pan3|PAN3]]|0.433|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.432|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.431|
|[[:human genes:s:slc6a17|SLC6A17]]|0.431|
|[[:human genes:r:rps3a|RPS3A]]|0.43|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.43|
|[[:human genes:c:chchd3|CHCHD3]]|0.43|
|[[:human genes:z:zfand5|ZFAND5]]|0.428|
|[[:human genes:s:sde2|SDE2]]|0.428|
|[[:human genes:p:psmb1|PSMB1]]|0.428|
|[[:human genes:p:ppan|PPAN]]|0.428|
|[[:human genes:e:exosc1|EXOSC1]]|0.427|
|[[:human genes:c:cdh24|CDH24]]|0.427|
|[[:human genes:r:rpa2|RPA2]]|0.422|
|[[:human genes:c:col2a1|COL2A1]]|0.421|
|[[:human genes:d:ddtl|DDTL]]|0.42|
|[[:human genes:v:vps28|VPS28]]|0.42|
|[[:human genes:n:ncapg|NCAPG]]|0.42|
|[[:human genes:p:psmc6|PSMC6]]|0.419|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.418|
|[[:human genes:e:exosc3|EXOSC3]]|0.417|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.417|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.417|
|[[:human genes:c:cgb2|CGB2]]|0.416|
|[[:human genes:m:mfsd12|MFSD12]]|0.416|
|[[:human genes:c:ccna2|CCNA2]]|0.413|
|[[:human genes:p:polr2d|POLR2D]]|0.413|
|[[:human genes:g:golga8o|GOLGA8O]]|0.413|
|[[:human genes:b:bysl|BYSL]]|0.413|
|[[:human genes:r:rrp12|RRP12]]|0.411|
|[[:human genes:r:rpl9|RPL9]]|0.41|
|[[:human genes:s:skiv2l2|SKIV2L2]]|0.41|
|[[:human genes:e:eif6|EIF6]]|0.41|
|[[:human genes:c:c19orf53|C19orf53]]|0.409|
|[[:human genes:d:ddt|DDT]]|0.409|
|[[:human genes:c:cacna1a|CACNA1A]]|0.409|
|[[:human genes:p:ppm1d|PPM1D]]|0.408|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.408|
|[[:human genes:z:znf574|ZNF574]]|0.408|
|[[:human genes:c:copg1|COPG1]]|0.407|
|[[:human genes:c:chmp4b|CHMP4B]]|0.406|
|[[:human genes:s:slc4a1|SLC4A1]]|0.403|
|[[:human genes:e:eftud2|EFTUD2]]|0.401|
|[[:human genes:t:ticrr|TICRR]]|0.401|
|[[:human genes:z:znf830|ZNF830]]|0.401|
|[[:human genes:t:tsg101|TSG101]]|0.401|
|[[:human genes:i:imp3|IMP3]]|0.4|
|[[:human genes:c:cbwd3|CBWD3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 555/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|22/28|
|blood|19/28|
|bone|15/26|
|breast|25/33|
|central nervous system|47/56|
|cervix|3/4|
|colorectal|13/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|17/21|
|liver|14/20|
|lung|55/75|
|lymphocyte|12/16|
|ovary|21/26|
|pancreas|17/24|
|peripheral nervous system|11/16|
|plasma cell|7/15|
|prostate|1/1|
|skin|16/24|
|soft tissue|9/9|
|thyroid|1/2|
|upper aerodigestive|19/22|
|urinary tract|20/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 772
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EBNA1BP2 Expression in NALM6 Cells: 6.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>