======= ECM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ECM1
  * **<color #00a2e8>Official Name</color>**: extracellular matrix protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1893|1893]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16610|Q16610]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ECM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ECM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602201|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ECM1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-2 receptor binding|
|platelet dense granule lumen|
|negative regulation of bone mineralization|
|laminin binding|
|negative regulation of biomineralization|
|negative regulation of biomineral tissue development|
|regulation of type 2 immune response|
|endochondral bone growth|
|chondrocyte development|
|regulation of T cell migration|
|bone growth|
|negative regulation of cytokine-mediated signaling pathway|
|regulation of lymphocyte migration|
|negative regulation of response to cytokine stimulus|
|negative regulation of ossification|
|regulation of bone mineralization|
|chondrocyte differentiation|
|regulation of biomineral tissue development|
|biomineral tissue development|
|regulation of biomineralization|
|biomineralization|
|positive regulation of endothelial cell proliferation|
|organ growth|
|protease binding|
|regulation of endothelial cell proliferation|
|platelet degranulation|
|extracellular matrix structural constituent|
|regulation of cytokine-mediated signaling pathway|
|positive regulation of angiogenesis|
|cartilage development|
|regulation of response to cytokine stimulus|
|positive regulation of vasculature development|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of epithelial cell proliferation|
|protein C-terminus binding|
|regulation of ossification|
|regulation of leukocyte migration|
|connective tissue development|
|extracellular matrix|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|negative regulation of peptidase activity|
|ossification|
|regulation of angiogenesis|
|angiogenesis|
|regulation of vasculature development|
|regulation of epithelial cell proliferation|
|enzyme binding|
|negative regulation of proteolysis|
|collagen-containing extracellular matrix|
|developmental growth|
|growth|
|blood vessel morphogenesis|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|blood vessel development|
|skeletal system development|
|inflammatory response|
|vasculature development|
|cardiovascular system development|
|tube morphogenesis|
|regulated exocytosis|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|exocytosis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|export from cell|
|regulation of anatomical structure morphogenesis|
|negative regulation of protein metabolic process|
|secretion|
|negative regulation of molecular function|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8287
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ECM1 Expression in NALM6 Cells: 1.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>