======= EDEM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EDEM1
  * **<color #00a2e8>Official Name</color>**: ER degradation enhancing alpha-mannosidase like protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9695|9695]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92611|Q92611]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EDEM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EDEM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607673|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2. {ECO:0000269|PubMed:12610306, ECO:0000269|PubMed:19524542, ECO:0000269|PubMed:19934218, ECO:0000269|PubMed:25092655}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco hydro 47|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|trimming of terminal mannose on C branch|
|positive regulation of retrograde protein transport, ER to cytosol|
|protein deglycosylation involved in glycoprotein catabolic process|
|ubiquitin-dependent glycoprotein ERAD pathway|
|mannose trimming involved in glycoprotein ERAD pathway|
|response to glycoprotein|
|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|
|regulation of retrograde protein transport, ER to cytosol|
|positive regulation of protein exit from endoplasmic reticulum|
|positive regulation of ERAD pathway|
|endoplasmic reticulum mannose trimming|
|protein alpha-1,2-demannosylation|
|protein demannosylation|
|glycoprotein catabolic process|
|endoplasmic reticulum quality control compartment|
|regulation of protein exit from endoplasmic reticulum|
|misfolded protein binding|
|regulation of ERAD pathway|
|protein deglycosylation|
|positive regulation of response to endoplasmic reticulum stress|
|aggresome|
|IRE1-mediated unfolded protein response|
|ubiquitin-dependent ERAD pathway|
|regulation of response to endoplasmic reticulum stress|
|ERAD pathway|
|positive regulation of proteasomal protein catabolic process|
|endoplasmic reticulum unfolded protein response|
|integral component of endoplasmic reticulum membrane|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|cellular response to unfolded protein|
|positive regulation of cellular protein catabolic process|
|cellular response to topologically incorrect protein|
|positive regulation of intracellular protein transport|
|response to unfolded protein|
|regulation of proteasomal protein catabolic process|
|response to topologically incorrect protein|
|carbohydrate derivative catabolic process|
|positive regulation of intracellular transport|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|regulation of intracellular protein transport|
|regulation of cellular protein catabolic process|
|response to endoplasmic reticulum stress|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|positive regulation of cellular protein localization|
|proteasomal protein catabolic process|
|regulation of intracellular transport|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|glycoprotein metabolic process|
|positive regulation of protein transport|
|positive regulation of catabolic process|
|positive regulation of establishment of protein localization|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cellular protein localization|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|regulation of protein transport|
|calcium ion binding|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cellular catabolic process|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|positive regulation of transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|regulation of protein localization|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|proteolysis|
|regulation of response to stress|
|response to oxygen-containing compound|
|positive regulation of cellular protein metabolic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8787
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EDEM1 Expression in NALM6 Cells: 8.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>