======= EEF2K =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EEF2K
  * **<color #00a2e8>Official Name</color>**: eukaryotic elongation factor 2 kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29904|29904]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00418|O00418]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EEF2K&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EEF2K|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606968|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Alpha kinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to anoxia|
|elongation factor-2 kinase activity|
|response to anoxia|
|response to prolactin|
|cellular response to brain-derived neurotrophic factor stimulus|
|positive regulation of dendritic spine morphogenesis|
|translation factor activity, RNA binding|
|positive regulation of dendrite morphogenesis|
|regulation of dendritic spine morphogenesis|
|positive regulation of dendritic spine development|
|regulation of protein autophosphorylation|
|cellular response to nerve growth factor stimulus|
|response to ischemia|
|response to nerve growth factor|
|cellular response to cAMP|
|positive regulation of synapse assembly|
|regulation of dendritic spine development|
|positive regulation of dendrite development|
|cellular response to calcium ion|
|regulation of dendrite morphogenesis|
|regulation of postsynapse organization|
|response to cAMP|
|positive regulation of endocytosis|
|regulation of synapse assembly|
|translational elongation|
|response to organophosphorus|
|dendritic spine|
|regulation of dendrite development|
|response to calcium ion|
|response to purine-containing compound|
|positive regulation of cell morphogenesis involved in differentiation|
|cellular response to insulin stimulus|
|cellular response to metal ion|
|protein autophosphorylation|
|cellular response to decreased oxygen levels|
|calmodulin binding|
|regulation of endocytosis|
|cellular response to oxygen levels|
|regulation of synapse organization|
|cellular response to inorganic substance|
|regulation of synapse structure or activity|
|response to insulin|
|protein kinase activity|
|postsynaptic density|
|cellular response to peptide hormone stimulus|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|cellular response to peptide|
|response to decreased oxygen levels|
|positive regulation of neuron differentiation|
|response to metal ion|
|response to oxygen levels|
|positive regulation of cell projection organization|
|translation|
|response to peptide hormone|
|peptide biosynthetic process|
|positive regulation of neurogenesis|
|response to peptide|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|positive regulation of cellular component biogenesis|
|amide biosynthetic process|
|peptide metabolic process|
|response to growth factor|
|response to inorganic substance|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cellular response to organic cyclic compound|
|regulation of vesicle-mediated transport|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|calcium ion binding|
|cellular amide metabolic process|
|regulation of neurogenesis|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|positive regulation of transport|
|negative regulation of cell death|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|phosphorylation|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|regulation of cell death|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|regulation of transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13832
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EEF2K Expression in NALM6 Cells: 6.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>