======= EFNA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EFNA1
  * **<color #00a2e8>Official Name</color>**: ephrin A1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1942|1942]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20827|P20827]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EFNA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EFNA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191164|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. {ECO:0000269|PubMed:17332925, ECO:0000269|PubMed:18794797}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ephrin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endocardial cushion to mesenchymal transition involved in heart valve formation|
|notochord formation|
|endocardial cushion to mesenchymal transition|
|negative regulation of dendritic spine morphogenesis|
|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|
|negative regulation of thymocyte apoptotic process|
|positive regulation of aspartic-type peptidase activity|
|regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|
|mitral valve morphogenesis|
|notochord morphogenesis|
|regulation of aspartic-type peptidase activity|
|mitral valve development|
|regulation of thymocyte apoptotic process|
|heart valve formation|
|negative regulation of dendritic spine development|
|positive regulation of amyloid-beta formation|
|negative regulation of dendrite morphogenesis|
|negative regulation of T cell apoptotic process|
|positive regulation of amyloid precursor protein catabolic process|
|notochord development|
|atrioventricular valve morphogenesis|
|negative regulation of synapse organization|
|atrioventricular valve development|
|negative regulation of epithelial to mesenchymal transition|
|regulation of amyloid-beta formation|
|aortic valve morphogenesis|
|negative regulation of lymphocyte apoptotic process|
|ephrin receptor binding|
|cardiac epithelial to mesenchymal transition|
|negative regulation of dendrite development|
|aortic valve development|
|anchored component of plasma membrane|
|regulation of T cell apoptotic process|
|regulation of amyloid precursor protein catabolic process|
|semi-lunar valve development|
|regulation of dendritic spine morphogenesis|
|regulation of cell adhesion mediated by integrin|
|negative regulation of leukocyte apoptotic process|
|heart valve morphogenesis|
|substrate adhesion-dependent cell spreading|
|regulation of lymphocyte apoptotic process|
|positive regulation of protein tyrosine kinase activity|
|heart valve development|
|epithelial to mesenchymal transition|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|regulation of dendritic spine development|
|regulation of leukocyte apoptotic process|
|regulation of epithelial to mesenchymal transition|
|negative regulation of cellular protein catabolic process|
|ephrin receptor signaling pathway|
|regulation of protein tyrosine kinase activity|
|regulation of blood vessel endothelial cell migration|
|regulation of dendrite morphogenesis|
|regulation of postsynapse organization|
|negative regulation of cell morphogenesis involved in differentiation|
|negative regulation of protein catabolic process|
|regulation of dendrite development|
|positive regulation of cellular amide metabolic process|
|negative regulation of neuron projection development|
|mesenchymal cell differentiation|
|regulation of endothelial cell migration|
|negative regulation of MAPK cascade|
|positive regulation of endopeptidase activity|
|protein stabilization|
|negative regulation of cell projection organization|
|cell-substrate adhesion|
|regulation of axonogenesis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of peptidase activity|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of synapse organization|
|regulation of epithelial cell migration|
|mesenchyme development|
|negative regulation of neuron differentiation|
|regulation of synapse structure or activity|
|regulation of cellular protein catabolic process|
|heart morphogenesis|
|negative regulation of cellular catabolic process|
|regulation of peptidyl-tyrosine phosphorylation|
|axon guidance|
|neuron projection guidance|
|regulation of angiogenesis|
|regulation of protein stability|
|embryonic organ morphogenesis|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of catabolic process|
|negative regulation of nervous system development|
|angiogenesis|
|regulation of vasculature development|
|negative regulation of cell development|
|signaling receptor binding|
|negative regulation of proteolysis|
|positive regulation of proteolysis|
|axonogenesis|
|regulation of protein catabolic process|
|regulation of cellular amide metabolic process|
|negative regulation of protein phosphorylation|
|blood vessel morphogenesis|
|axon development|
|regulation of endopeptidase activity|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|negative regulation of phosphorylation|
|regulation of peptidase activity|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|negative regulation of intracellular signal transduction|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|cardiovascular system development|
|heart development|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|embryonic morphogenesis|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|tube morphogenesis|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of proteolysis|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|tube development|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|regulation of transferase activity|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of catabolic process|
|negative regulation of cell death|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.73|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.74|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.81|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.506|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4371
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EFNA1 Expression in NALM6 Cells: -0.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>