======= EFNA5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EFNA5
  * **<color #00a2e8>Official Name</color>**: ephrin A5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1946|1946]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52803|P52803]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EFNA5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EFNA5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601535|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion. {ECO:0000269|PubMed:10601038, ECO:0000269|PubMed:11870224}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ephrin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neurotrophin TRKC receptor binding|
|neurotrophin TRKB receptor binding|
|neurotrophin TRKA receptor binding|
|transmembrane receptor protein tyrosine kinase activator activity|
|collateral sprouting|
|response to forskolin|
|positive regulation of collateral sprouting|
|cellular response to follicle-stimulating hormone stimulus|
|cellular response to forskolin|
|negative regulation of substrate adhesion-dependent cell spreading|
|activation of transmembrane receptor protein tyrosine kinase activity|
|response to platelet aggregation inhibitor|
|response to follicle-stimulating hormone|
|cellular response to gonadotropin stimulus|
|retinal ganglion cell axon guidance|
|anchored component of external side of plasma membrane|
|regulation of collateral sprouting|
|synaptic membrane adhesion|
|chemorepellent activity|
|response to gonadotropin|
|ephrin receptor binding|
|negative chemotaxis|
|regulation of substrate adhesion-dependent cell spreading|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|regulation of cell-substrate junction assembly|
|regulation of focal adhesion assembly|
|negative regulation of cell-substrate adhesion|
|adherens junction|
|positive regulation of synapse assembly|
|regulation of adherens junction organization|
|GABA-ergic synapse|
|caveola|
|cellular response to alcohol|
|positive regulation of axonogenesis|
|ephrin receptor signaling pathway|
|developmental cell growth|
|basement membrane|
|regulation of cell junction assembly|
|cell growth|
|cellular response to ketone|
|negative regulation of cell morphogenesis involved in differentiation|
|regulation of synapse assembly|
|regulation of extent of cell growth|
|regulation of cell-matrix adhesion|
|developmental growth involved in morphogenesis|
|cellular response to antibiotic|
|positive regulation of cell morphogenesis involved in differentiation|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|regulation of insulin secretion|
|regulation of cell size|
|regulation of axonogenesis|
|regulation of microtubule cytoskeleton organization|
|positive regulation of peptidyl-tyrosine phosphorylation|
|response to ketone|
|regulation of peptide hormone secretion|
|regulation of cell-substrate adhesion|
|regulation of synapse organization|
|regulation of microtubule-based process|
|regulation of synapse structure or activity|
|response to alcohol|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of growth|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|axon guidance|
|neuron projection guidance|
|regulation of hormone secretion|
|synapse organization|
|negative regulation of cell adhesion|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|response to antibiotic|
|activation of protein kinase activity|
|regulation of developmental growth|
|negative regulation of cell development|
|regulation of actin cytoskeleton organization|
|positive regulation of neuron differentiation|
|axonogenesis|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|developmental growth|
|regulation of actin filament-based process|
|growth|
|regulation of cell-cell adhesion|
|cellular response to drug|
|axon development|
|regulation of cell growth|
|cell morphogenesis involved in neuron differentiation|
|regulation of protein secretion|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of peptide secretion|
|regulation of neuron projection development|
|cell-cell adhesion|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|cellular response to lipid|
|positive regulation of protein kinase activity|
|regulation of hormone levels|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|positive regulation of kinase activity|
|cellular response to hormone stimulus|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|neuron projection development|
|regulation of growth|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of protein kinase activity|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|response to lipid|
|regulation of kinase activity|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|regulation of protein localization|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell death|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|regulation of organelle organization|
|locomotion|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.8|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.77|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.9|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|2.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12831
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EFNA5 Expression in NALM6 Cells: 1.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>