======= EIF2AK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF2AK1
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 2 alpha kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27102|27102]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BQI3|Q9BQI3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF2AK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF2AK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613635|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of translational initiation by iron|
|negative regulation of hemoglobin biosynthetic process|
|regulation of eIF2 alpha phosphorylation by heme|
|regulation of translational initiation by iron|
|response to iron ion starvation|
|regulation of hemoglobin biosynthetic process|
|regulation of translational initiation by eIF2 alpha phosphorylation|
|eukaryotic translation initiation factor 2alpha kinase activity|
|regulation of translational initiation in response to stress|
|protoporphyrinogen IX metabolic process|
|regulation of translation in response to stress|
|negative regulation of translational initiation|
|macrophage differentiation|
|porphyrin-containing compound metabolic process|
|tetrapyrrole metabolic process|
|acute inflammatory response|
|regulation of translational initiation|
|iron ion homeostasis|
|myeloid leukocyte differentiation|
|negative regulation of translation|
|transition metal ion homeostasis|
|heme binding|
|negative regulation of cellular amide metabolic process|
|protein autophosphorylation|
|response to starvation|
|myeloid cell differentiation|
|protein kinase activity|
|phagocytosis|
|leukocyte differentiation|
|regulation of translation|
|regulation of cellular amide metabolic process|
|cofactor metabolic process|
|response to nutrient levels|
|inflammatory response|
|posttranscriptional regulation of gene expression|
|response to extracellular stimulus|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|metal ion homeostasis|
|immune system development|
|negative regulation of cell population proliferation|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of cellular response to stress|
|ion homeostasis|
|protein homodimerization activity|
|protein phosphorylation|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|phosphorylation|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|homeostatic process|
|cellular response to stress|
|negative regulation of gene expression|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.73|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.74|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.76|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.77|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.81|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.81|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.84|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.86|
|[[:results:exp302|35°C R06 exp302]]|1.89|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.93|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.99|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.03|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.07|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.19|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.22|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.57|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.65|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kiaa0141|KIAA0141]]|0.47|
|[[:human genes:o:oma1|OMA1]]|0.419|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 251
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF2AK1 Expression in NALM6 Cells: 7.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>