======= EIF2S1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF2S1
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 2 subunit alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1965|1965]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05198|P05198]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF2S1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF2S1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603907|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2- GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EIF 2 alpha|
|S1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translation initiation ternary complex|
|multi-eIF complex|
|positive regulation of type B pancreatic cell apoptotic process|
|response to manganese-induced endoplasmic reticulum stress|
|glial limiting end-foot|
|negative regulation of translational initiation in response to stress|
|negative regulation of guanyl-nucleotide exchange factor activity|
|eukaryotic translation initiation factor 2 complex|
|eukaryotic translation initiation factor 2B complex|
|negative regulation of translation in response to stress|
|regulation of guanyl-nucleotide exchange factor activity|
|regulation of type B pancreatic cell apoptotic process|
|regulation of translational initiation in response to stress|
|cellular response to manganese ion|
|PERK-mediated unfolded protein response|
|regulation of GTP binding|
|eukaryotic 48S preinitiation complex|
|regulation of translation in response to stress|
|stress granule assembly|
|negative regulation of translational initiation|
|response to manganese ion|
|positive regulation of epithelial cell apoptotic process|
|ER-nucleus signaling pathway|
|cellular response to amino acid starvation|
|polysome|
|response to amino acid starvation|
|translation initiation factor activity|
|ribosome binding|
|cytoplasmic stress granule|
|cellular response to heat|
|regulation of translational initiation|
|regulation of epithelial cell apoptotic process|
|cellular response to UV|
|positive regulation of neuron death|
|negative regulation of protein binding|
|endoplasmic reticulum unfolded protein response|
|response to heat|
|cellular response to light stimulus|
|cellular response to unfolded protein|
|negative regulation of translation|
|response to UV|
|translational initiation|
|negative regulation of cellular amide metabolic process|
|cellular response to topologically incorrect protein|
|cellular response to starvation|
|response to unfolded protein|
|negative regulation of binding|
|cellular response to radiation|
|response to temperature stimulus|
|positive regulation of binding|
|response to topologically incorrect protein|
|cellular response to metal ion|
|response to starvation|
|protein autophosphorylation|
|regulation of protein binding|
|cellular response to inorganic substance|
|ribonucleoprotein complex assembly|
|cellular response to nutrient levels|
|cellular response to oxidative stress|
|ribonucleoprotein complex subunit organization|
|response to endoplasmic reticulum stress|
|cellular response to extracellular stimulus|
|synapse|
|aging|
|response to light stimulus|
|regulation of neuron death|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|cellular response to external stimulus|
|regulation of translation|
|response to metal ion|
|regulation of binding|
|translation|
|response to oxidative stress|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|response to radiation|
|ribonucleoprotein complex biogenesis|
|response to nutrient levels|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|response to extracellular stimulus|
|response to inorganic substance|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|organelle assembly|
|cellular amide metabolic process|
|cellular protein-containing complex assembly|
|protein phosphorylation|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|transmembrane transport|
|phosphorylation|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|cellular nitrogen compound biosynthetic process|
|regulation of cell death|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.84|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.47|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.94|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.77|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|1.71|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.86|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.89|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.92|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.99|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|2.32|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|2.43|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|2.52|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.54|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.81|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|2.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mcrs1|MCRS1]]|0.422|
|[[:human genes:m:myc|MYC]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 292
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF2S1 Expression in NALM6 Cells: 7.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>