======= EIF3B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF3B
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 3 subunit B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8662|8662]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55884|P55884]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF3B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF3B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603917|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:9388245, PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:9388245, PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815, ECO:0000269|PubMed:9388245}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|eIF2A|
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|viral translational termination-reinitiation|
|eukaryotic translation initiation factor 3 complex, eIF3m|
|IRES-dependent viral translational initiation|
|viral translation|
|eukaryotic 48S preinitiation complex|
|eukaryotic translation initiation factor 3 complex|
|formation of cytoplasmic translation initiation complex|
|eukaryotic 43S preinitiation complex|
|translation initiation factor binding|
|cytoplasmic translational initiation|
|molecular adaptor activity|
|translation initiation factor activity|
|cytoplasmic translation|
|regulation of translational initiation|
|viral gene expression|
|translational initiation|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|synapse|
|regulation of translation|
|translation|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|ribonucleoprotein complex biogenesis|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|viral process|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2.7|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-2.18|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.99|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.99|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.9|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-1.85|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.83|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.8|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.77|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.77|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.76|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.73|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.72|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.7|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.77|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|1.81|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.84|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.85|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.92|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.93|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.94|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.02|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.02|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|2.04|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.17|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|2.19|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.26|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.29|
|[[:results:exp124|GSK343 3μM R03 exp124]]|2.38|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.42|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.46|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.53|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.59|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.75|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|3.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 704/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|25/28|
|bone|24/26|
|breast|30/33|
|central nervous system|55/56|
|cervix|3/4|
|colorectal|15/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|21/21|
|liver|17/20|
|lung|71/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1383
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF3B Expression in NALM6 Cells: 8.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>