======= EIF3F =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF3F
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 3 subunit F
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8665|8665]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00303|O00303]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF3F&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF3F|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603914|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF- 3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03005, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mov34|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|eukaryotic translation initiation factor 3 complex, eIF3m|
|IRES-dependent viral translational initiation|
|viral translation|
|eukaryotic 48S preinitiation complex|
|eukaryotic translation initiation factor 3 complex|
|formation of cytoplasmic translation initiation complex|
|eukaryotic 43S preinitiation complex|
|translation initiation factor binding|
|cytoplasmic translational initiation|
|translation initiation factor activity|
|cytoplasmic translation|
|thiol-dependent ubiquitin-specific protease activity|
|viral gene expression|
|translational initiation|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|protein deubiquitination|
|protein modification by small protein removal|
|translation|
|peptide biosynthetic process|
|ribonucleoprotein complex biogenesis|
|amide biosynthetic process|
|peptide metabolic process|
|viral process|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|protein modification by small protein conjugation or removal|
|proteolysis|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.85|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.84|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.83|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-1.8|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-1.75|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.74|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.73|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.75|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.78|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.79|
|[[:results:exp539|42°C R08 exp539]]|1.87|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.87|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.87|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.88|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.96|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|2.06|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|2.09|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.1|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.26|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.48|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.51|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.56|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.9|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|3.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.639|
|[[:human genes:g:gmppb|GMPPB]]|0.548|
|[[:human genes:r:rptor|RPTOR]]|0.525|
|[[:human genes:t:thg1l|THG1L]]|0.518|
|[[:human genes:s:srp14|SRP14]]|0.511|
|[[:human genes:u:uap1|UAP1]]|0.505|
|[[:human genes:a:adsl|ADSL]]|0.5|
|[[:human genes:e:eftud1|EFTUD1]]|0.498|
|[[:human genes:t:triap1|TRIAP1]]|0.491|
|[[:human genes:p:pmm2|PMM2]]|0.49|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.49|
|[[:human genes:u:uhrf1|UHRF1]]|0.483|
|[[:human genes:h:hccs|HCCS]]|0.481|
|[[:human genes:t:tamm41|TAMM41]]|0.477|
|[[:human genes:c:chchd4|CHCHD4]]|0.476|
|[[:human genes:t:ten1|TEN1]]|0.471|
|[[:human genes:h:hspd1|HSPD1]]|0.468|
|[[:human genes:g:gfpt1|GFPT1]]|0.467|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.464|
|[[:human genes:g:gemin8|GEMIN8]]|0.464|
|[[:human genes:l:lsm10|LSM10]]|0.462|
|[[:human genes:n:n6amt1|N6AMT1]]|0.457|
|[[:human genes:e:eif4e|EIF4E]]|0.454|
|[[:human genes:r:rnmt|RNMT]]|0.453|
|[[:human genes:d:dhrsx|DHRSX]]|0.453|
|[[:human genes:u:urm1|URM1]]|0.452|
|[[:human genes:a:atxn10|ATXN10]]|0.452|
|[[:human genes:z:znhit1|ZNHIT1]]|0.452|
|[[:human genes:b:bak1|BAK1]]|0.451|
|[[:human genes:r:rpe|RPE]]|0.45|
|[[:human genes:c:cycs|CYCS]]|0.449|
|[[:human genes:d:dohh|DOHH]]|0.445|
|[[:human genes:r:rpp21|RPP21]]|0.444|
|[[:human genes:a:apaf1|APAF1]]|0.439|
|[[:human genes:e:eny2|ENY2]]|0.438|
|[[:human genes:a:alg13|ALG13]]|0.438|
|[[:human genes:t:taz|TAZ]]|0.437|
|[[:human genes:l:lsm11|LSM11]]|0.436|
|[[:human genes:a:abcf1|ABCF1]]|0.435|
|[[:human genes:v:vezt|VEZT]]|0.435|
|[[:human genes:m:mtor|MTOR]]|0.435|
|[[:human genes:r:rbmx2|RBMX2]]|0.434|
|[[:human genes:t:tsen54|TSEN54]]|0.431|
|[[:human genes:t:taf1a|TAF1A]]|0.431|
|[[:human genes:t:tmem41b|TMEM41B]]|0.43|
|[[:human genes:u:uqcr10|UQCR10]]|0.43|
|[[:human genes:b:bcs1l|BCS1L]]|0.429|
|[[:human genes:p:ppa2|PPA2]]|0.428|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.428|
|[[:human genes:d:dpf2|DPF2]]|0.427|
|[[:human genes:o:obfc1|OBFC1]]|0.427|
|[[:human genes:c:cct7|CCT7]]|0.427|
|[[:human genes:e:elac2|ELAC2]]|0.426|
|[[:human genes:t:telo2|TELO2]]|0.425|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.424|
|[[:human genes:n:ndufb1|NDUFB1]]|0.423|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.422|
|[[:human genes:t:trnt1|TRNT1]]|0.422|
|[[:human genes:s:slc25a26|SLC25A26]]|0.421|
|[[:human genes:r:rtcb|RTCB]]|0.421|
|[[:human genes:p:pelo|PELO]]|0.421|
|[[:human genes:t:tti2|TTI2]]|0.419|
|[[:human genes:p:plaa|PLAA]]|0.418|
|[[:human genes:d:dpagt1|DPAGT1]]|0.418|
|[[:human genes:t:tgs1|TGS1]]|0.417|
|[[:human genes:g:gemin6|GEMIN6]]|0.416|
|[[:human genes:a:alg1|ALG1]]|0.415|
|[[:human genes:r:rpia|RPIA]]|0.414|
|[[:human genes:t:tbca|TBCA]]|0.414|
|[[:human genes:e:eprs|EPRS]]|0.413|
|[[:human genes:d:dhps|DHPS]]|0.413|
|[[:human genes:p:ppcs|PPCS]]|0.412|
|[[:human genes:w:wdr24|WDR24]]|0.411|
|[[:human genes:a:atp5a1|ATP5A1]]|0.41|
|[[:human genes:h:haus8|HAUS8]]|0.41|
|[[:human genes:o:oraov1|ORAOV1]]|0.407|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.406|
|[[:human genes:m:mrps14|MRPS14]]|0.405|
|[[:human genes:a:actc1|ACTC1]]|0.405|
|[[:human genes:g:gemin7|GEMIN7]]|0.405|
|[[:human genes:p:ppp4c|PPP4C]]|0.404|
|[[:human genes:g:gnb1l|GNB1L]]|0.401|
|[[:human genes:c:c17orf89|C17orf89]]|0.4|
|[[:human genes:c:crls1|CRLS1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 296/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|13/28|
|bone|12/26|
|breast|13/33|
|central nervous system|25/56|
|cervix|2/4|
|colorectal|5/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|8/21|
|liver|9/20|
|lung|28/75|
|lymphocyte|9/16|
|ovary|12/26|
|pancreas|12/24|
|peripheral nervous system|11/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|10/24|
|soft tissue|5/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|12/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4490
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF3F Expression in NALM6 Cells: 7.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>