======= EIF3M =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF3M
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 3 subunit M
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10480|10480]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7L2H7|Q7L2H7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF3M&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF3M|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609641|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17403899, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17403899). The eIF- 3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03012, ECO:0000269|PubMed:17403899, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PCI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|eukaryotic translation initiation factor 3 complex, eIF3m|
|eukaryotic 48S preinitiation complex|
|eukaryotic translation initiation factor 3 complex|
|formation of cytoplasmic translation initiation complex|
|eukaryotic 43S preinitiation complex|
|translation initiation factor binding|
|cytoplasmic translational initiation|
|translation initiation factor activity|
|cytoplasmic translation|
|translational initiation|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|translation|
|peptide biosynthetic process|
|ribonucleoprotein complex biogenesis|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|cellular protein-containing complex assembly|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-2.1|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.8|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.82|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.86|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.87|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.93|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|2.24|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.39|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.41|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.42|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:eif4g1|EIF4G1]]|0.444|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 570/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|21/28|
|blood|21/28|
|bone|19/26|
|breast|25/33|
|central nervous system|46/56|
|cervix|3/4|
|colorectal|10/17|
|esophagus|9/13|
|fibroblast|0/1|
|gastric|9/16|
|kidney|17/21|
|liver|16/20|
|lung|60/75|
|lymphocyte|14/16|
|ovary|22/26|
|pancreas|15/24|
|peripheral nervous system|15/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|19/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|6/22|
|urinary tract|24/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2338
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.85 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF3M Expression in NALM6 Cells: 7.85'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>