======= EIF4A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF4A1
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 4A1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1973|1973]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P60842|P60842]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF4A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF4A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602641|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DEAD|
|Helicase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA cap binding|
|eukaryotic translation initiation factor 4F complex|
|translation factor activity, RNA binding|
|cytoplasmic translational initiation|
|helicase activity|
|translation initiation factor activity|
|RNA helicase activity|
|double-stranded RNA binding|
|cytoplasmic translation|
|translational initiation|
|mRNA binding|
|translation|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|viral process|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|RNA binding|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.57|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.38|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.34|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-2.05|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.02|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.93|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.82|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.78|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.7|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.7|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.71|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|1.72|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.72|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.73|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.73|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.73|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.74|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.76|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.8|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.83|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.84|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.85|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.89|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.9|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.99|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.01|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.02|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.1|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.11|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.13|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.14|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.18|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.18|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|2.22|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.22|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.22|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.23|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2.26|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.26|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2.27|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.3|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.31|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|2.31|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.35|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.38|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.4|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.42|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.53|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.59|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.59|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.59|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.69|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|2.71|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.77|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.78|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.8|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.84|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.91|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.99|
|[[:results:exp461|BS-181 20μM R08 exp461]]|3|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|3.04|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|3.04|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|3.06|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|3.08|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|3.13|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|3.14|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|3.19|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|3.2|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|3.21|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|3.37|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|3.47|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|3.51|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|3.52|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|3.57|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|3.57|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|3.58|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|3.63|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.83|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|3.86|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|3.93|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|4.03|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|4.08|
|[[:results:exp504|MK2206 4μM R08 exp504]]|4.1|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|4.33|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|4.41|
|[[:results:exp210|LB-100 2μM R05 exp210]]|4.42|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|4.44|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|4.5|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|4.5|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|4.5|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|4.54|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|4.6|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|4.63|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|4.65|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|4.95|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|5.31|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|5.45|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|6.11|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|7.24|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|7.54|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|7.61|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|7.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rps25|RPS25]]|0.46|
|[[:human genes:z:zfc3h1|ZFC3H1]]|0.456|
|[[:human genes:c:ccnl1|CCNL1]]|0.44|
|[[:human genes:e:eif3g|EIF3G]]|0.433|
|[[:human genes:c:c9orf78|C9orf78]]|0.413|
|[[:human genes:i:ikzf2|IKZF2]]|0.409|
|[[:human genes:p:pmaip1|PMAIP1]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 679/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|27/28|
|bone|24/26|
|breast|30/33|
|central nervous system|51/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|11/13|
|fibroblast|0/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|68/75|
|lymphocyte|16/16|
|ovary|20/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|14/15|
|prostate|0/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|17/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2493
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF4A1 Expression in NALM6 Cells: 9.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>