======= EIF4E2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF4E2
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 4E family member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9470|9470]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60573|O60573]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF4E2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF4E2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605895|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity). {ECO:0000250|UniProtKB:Q8BMB3, ECO:0000269|PubMed:17368478, ECO:0000269|PubMed:22751931, ECO:0000269|PubMed:25624349, ECO:0000269|PubMed:9582349}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IF4E|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA cap binding|
|mRNA cap binding complex|
|RNA 7-methylguanosine cap binding|
|eukaryotic translation initiation factor 4F complex|
|translation factor activity, RNA binding|
|translation initiation factor activity|
|negative regulation of translation|
|translational initiation|
|negative regulation of cellular amide metabolic process|
|ubiquitin protein ligase binding|
|regulation of translation|
|in utero embryonic development|
|translation|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|cellular amide metabolic process|
|embryo development|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-3|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.7|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.48|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.21|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.15|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.05|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-2.02|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.99|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.96|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.94|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.94|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.82|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.8|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.78|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.78|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.75|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2217
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF4E2 Expression in NALM6 Cells: 5.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>