======= ELF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ELF1
  * **<color #00a2e8>Official Name</color>**: E74 like ETS transcription factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1997|1997]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P32519|P32519]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ELF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ELF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/189973|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. {ECO:0000269|PubMed:8756667}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ets|
|Elf-1 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of T cell receptor signaling pathway|
|regulation of B cell receptor signaling pathway|
|negative regulation of antigen receptor-mediated signaling pathway|
|regulation of T cell receptor signaling pathway|
|regulation of antigen receptor-mediated signaling pathway|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|negative regulation of immune system process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|DNA-binding transcription factor activity|
|regulation of cytokine production|
|regulation of immune response|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.42|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.9|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.7|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.76|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.86|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.87|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.89|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.89|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.93|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.99|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|2.09|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|2.23|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.27|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.49|
|[[:results:exp518|RK-33 8μM R08 exp518]]|2.65|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.8|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.92|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|3.02|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|3.03|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|3.08|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|3.09|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.1|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|3.25|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|4.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:g3bp1|G3BP1]]|0.48|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5258
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ELF1 Expression in NALM6 Cells: 7.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>