======= ELP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ELP2
  * **<color #00a2e8>Official Name</color>**: elongator acetyltransferase complex subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55250|55250]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6IA86|Q6IA86]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ELP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ELP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616054|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effects transcriptional elongation and may help remodel chromatin. [provided by RefSeq, May 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Elongator holoenzyme complex|
|tRNA wobble uridine modification|
|tRNA wobble base modification|
|transcription elongation factor complex|
|RNA polymerase II complex binding|
|transcription elongation from RNA polymerase II promoter|
|tRNA modification|
|DNA-templated transcription, elongation|
|tRNA processing|
|RNA modification|
|tRNA metabolic process|
|ncRNA processing|
|ncRNA metabolic process|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.93|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-1.92|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.92|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.72|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.72|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.76|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.77|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.92|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.97|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.1|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.13|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.44|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.63|
|[[:results:exp135|MS023 7μM R03 exp135]]|3.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:elp3|ELP3]]|0.735|
|[[:human genes:u:urm1|URM1]]|0.733|
|[[:human genes:e:elp6|ELP6]]|0.712|
|[[:human genes:c:ctu1|CTU1]]|0.708|
|[[:human genes:k:kti12|KTI12]]|0.682|
|[[:human genes:d:dph3|DPH3]]|0.65|
|[[:human genes:m:mocs3|MOCS3]]|0.628|
|[[:human genes:c:ctu2|CTU2]]|0.608|
|[[:human genes:t:thg1l|THG1L]]|0.599|
|[[:human genes:r:rpp21|RPP21]]|0.555|
|[[:human genes:e:elp5|ELP5]]|0.545|
|[[:human genes:e:elp4|ELP4]]|0.544|
|[[:human genes:n:nr2c2ap|NR2C2AP]]|0.536|
|[[:human genes:f:fam98b|FAM98B]]|0.528|
|[[:human genes:a:atxn10|ATXN10]]|0.523|
|[[:human genes:d:ddx1|DDX1]]|0.518|
|[[:human genes:a:atic|ATIC]]|0.506|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.505|
|[[:human genes:i:ikbkap|IKBKAP]]|0.5|
|[[:human genes:d:dohh|DOHH]]|0.497|
|[[:human genes:e:exoc4|EXOC4]]|0.497|
|[[:human genes:e:eef1e1|EEF1E1]]|0.496|
|[[:human genes:t:tsen54|TSEN54]]|0.493|
|[[:human genes:a:alg1|ALG1]]|0.482|
|[[:human genes:v:vezt|VEZT]]|0.482|
|[[:human genes:f:fh|FH]]|0.478|
|[[:human genes:s:ssb|SSB]]|0.474|
|[[:human genes:o:osgep|OSGEP]]|0.474|
|[[:human genes:s:sbds|SBDS]]|0.474|
|[[:human genes:k:kdsr|KDSR]]|0.473|
|[[:human genes:u:uap1|UAP1]]|0.468|
|[[:human genes:d:dph1|DPH1]]|0.468|
|[[:human genes:r:rtcb|RTCB]]|0.465|
|[[:human genes:d:dph5|DPH5]]|0.458|
|[[:human genes:g:gemin6|GEMIN6]]|0.457|
|[[:human genes:d:dhrsx|DHRSX]]|0.451|
|[[:human genes:d:dolk|DOLK]]|0.448|
|[[:human genes:n:n6amt1|N6AMT1]]|0.448|
|[[:human genes:i:itpa|ITPA]]|0.443|
|[[:human genes:d:dpagt1|DPAGT1]]|0.442|
|[[:human genes:t:ten1|TEN1]]|0.441|
|[[:human genes:r:rfk|RFK]]|0.441|
|[[:human genes:a:adsl|ADSL]]|0.438|
|[[:human genes:r:rpia|RPIA]]|0.435|
|[[:human genes:p:pmm2|PMM2]]|0.434|
|[[:human genes:l:lsm11|LSM11]]|0.432|
|[[:human genes:p:pdap1|PDAP1]]|0.432|
|[[:human genes:l:lsm10|LSM10]]|0.431|
|[[:human genes:d:ddx39a|DDX39A]]|0.428|
|[[:human genes:e:eif1ax|EIF1AX]]|0.426|
|[[:human genes:t:tkt|TKT]]|0.426|
|[[:human genes:s:slc25a19|SLC25A19]]|0.426|
|[[:human genes:r:rnaseh2b|RNASEH2B]]|0.425|
|[[:human genes:e:eftud1|EFTUD1]]|0.424|
|[[:human genes:p:ppcs|PPCS]]|0.423|
|[[:human genes:p:ppp6c|PPP6C]]|0.422|
|[[:human genes:k:kdm8|KDM8]]|0.417|
|[[:human genes:p:pgm3|PGM3]]|0.415|
|[[:human genes:d:dnlz|DNLZ]]|0.414|
|[[:human genes:c:c7orf26|C7orf26]]|0.413|
|[[:human genes:g:gemin8|GEMIN8]]|0.412|
|[[:human genes:t:trmt5|TRMT5]]|0.411|
|[[:human genes:p:pik3r4|PIK3R4]]|0.41|
|[[:human genes:r:rft1|RFT1]]|0.407|
|[[:human genes:c:c14orf166|C14orf166]]|0.406|
|[[:human genes:s:snapc5|SNAPC5]]|0.405|
|[[:human genes:m:msto1|MSTO1]]|0.405|
|[[:human genes:t:triap1|TRIAP1]]|0.405|
|[[:human genes:r:rabggtb|RABGGTB]]|0.404|
|[[:human genes:d:dr1|DR1]]|0.402|
|[[:human genes:a:alg6|ALG6]]|0.402|
|[[:human genes:s:srp14|SRP14]]|0.4|
|[[:human genes:w:wdr92|WDR92]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 123/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|8/28|
|blood|2/28|
|bone|3/25|
|breast|6/33|
|central nervous system|11/56|
|cervix|0/4|
|colorectal|5/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|3/15|
|kidney|7/21|
|liver|1/20|
|lung|13/75|
|lymphocyte|1/14|
|ovary|3/26|
|pancreas|5/24|
|peripheral nervous system|3/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|12/24|
|soft tissue|1/7|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|5/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2553
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ELP2 Expression in NALM6 Cells: 6.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>