======= ELP5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ELP5
  * **<color #00a2e8>Official Name</color>**: elongator acetyltransferase complex subunit 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23587|23587]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TE02|Q8TE02]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ELP5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ELP5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615019|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation. {ECO:0000250, ECO:0000269|PubMed:16850183}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hap2 elong|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Elongator holoenzyme complex|
|tRNA wobble uridine modification|
|tRNA wobble base modification|
|tRNA modification|
|tRNA processing|
|RNA modification|
|tRNA metabolic process|
|ncRNA processing|
|ncRNA metabolic process|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|regulation of cell migration|
|RNA processing|
|regulation of cell motility|
|regulation of locomotion|
|regulation of cellular component movement|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.72|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.79|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.81|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.08|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.18|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.2|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.26|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.3|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.35|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|3.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:elp6|ELP6]]|0.613|
|[[:human genes:k:kti12|KTI12]]|0.606|
|[[:human genes:c:ctu1|CTU1]]|0.559|
|[[:human genes:e:elp3|ELP3]]|0.557|
|[[:human genes:e:elp2|ELP2]]|0.545|
|[[:human genes:m:mocs3|MOCS3]]|0.543|
|[[:human genes:d:dph3|DPH3]]|0.529|
|[[:human genes:u:urm1|URM1]]|0.525|
|[[:human genes:c:ctu2|CTU2]]|0.523|
|[[:human genes:n:nr2c2ap|NR2C2AP]]|0.465|
|[[:human genes:e:elp4|ELP4]]|0.446|
|[[:human genes:i:ikbkap|IKBKAP]]|0.425|
|[[:human genes:f:fam98b|FAM98B]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 676/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|24/28|
|bone|25/26|
|breast|25/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|20/21|
|liver|20/20|
|lung|67/75|
|lymphocyte|15/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|28/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1222
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ELP5 Expression in NALM6 Cells: 5.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>