======= EMB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EMB
  * **<color #00a2e8>Official Name</color>**: embigin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=133418|133418]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6PCB8|Q6PCB8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EMB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EMB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615669|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|plasma membrane lactate transport|
|lactate transport|
|lactate transmembrane transport|
|dendrite self-avoidance|
|cell-cell adhesion mediator activity|
|neuron recognition|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|monocarboxylic acid transport|
|organic hydroxy compound transport|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|cell recognition|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|axon guidance|
|neuron projection guidance|
|synapse|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|axon|
|axonogenesis|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|organic anion transport|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell-cell adhesion|
|cell part morphogenesis|
|cell junction|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|anion transport|
|neuron projection development|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|cell adhesion|
|biological adhesion|
|ion transmembrane transport|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|transmembrane transport|
|locomotion|
|ion transport|
|integral component of plasma membrane|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12797
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EMB Expression in NALM6 Cells: 6.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>