======= EMD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EMD
  * **<color #00a2e8>Official Name</color>**: emerin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2010|2010]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50402|P50402]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EMD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EMD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300384|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta- catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C. {ECO:0000269|PubMed:15328537, ECO:0000269|PubMed:16680152, ECO:0000269|PubMed:16858403, ECO:0000269|PubMed:17785515, ECO:0000269|PubMed:19323649}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LEM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cortical endoplasmic reticulum|
|mitotic nuclear envelope reassembly|
|spindle pole centrosome|
|nuclear envelope reassembly|
|positive regulation of protein export from nucleus|
|nuclear outer membrane|
|negative regulation of fibroblast proliferation|
|beta-tubulin binding|
|regulation of protein export from nucleus|
|nuclear inner membrane|
|skeletal muscle cell differentiation|
|nuclear envelope organization|
|positive regulation of nucleocytoplasmic transport|
|regulation of fibroblast proliferation|
|regulation of nucleocytoplasmic transport|
|spindle|
|skeletal muscle tissue development|
|nucleus organization|
|skeletal muscle organ development|
|positive regulation of intracellular protein transport|
|negative regulation of canonical Wnt signaling pathway|
|nuclear envelope|
|positive regulation of intracellular transport|
|negative regulation of Wnt signaling pathway|
|regulation of intracellular protein transport|
|nuclear membrane|
|muscle contraction|
|actin binding|
|regulation of canonical Wnt signaling pathway|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|cadherin binding|
|microtubule|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|regulation of Wnt signaling pathway|
|endomembrane system organization|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|muscle structure development|
|cellular response to growth factor stimulus|
|response to growth factor|
|regulation of cellular protein localization|
|mitotic cell cycle process|
|negative regulation of cell population proliferation|
|mitotic cell cycle|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|membrane organization|
|regulation of cellular localization|
|positive regulation of transport|
|cell cycle process|
|endoplasmic reticulum|
|regulation of protein localization|
|negative regulation of signal transduction|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|tissue development|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.71|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.84|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|2.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.501|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12952
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EMD Expression in NALM6 Cells: 5.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>