======= ENDOG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ENDOG
  * **<color #00a2e8>Official Name</color>**: endonuclease G
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2021|2021]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14249|Q14249]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ENDOG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ENDOG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600440|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Endonuclease NS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neuron death in response to oxidative stress|
|exodeoxyribonuclease activity|
|positive regulation of hydrogen peroxide-mediated programmed cell death|
|positive regulation of hydrogen peroxide-induced cell death|
|positive regulation of apoptotic DNA fragmentation|
|positive regulation of DNA catabolic process|
|positive regulation of response to reactive oxygen species|
|single-stranded DNA endodeoxyribonuclease activity|
|regulation of hydrogen peroxide-mediated programmed cell death|
|regulation of apoptotic DNA fragmentation|
|positive regulation of cellular response to drug|
|regulation of DNA catabolic process|
|positive regulation of execution phase of apoptosis|
|positive regulation of oxidative stress-induced cell death|
|apoptotic DNA fragmentation|
|positive regulation of cellular response to oxidative stress|
|positive regulation of response to oxidative stress|
|cell death in response to oxidative stress|
|regulation of hydrogen peroxide-induced cell death|
|DNA catabolic process, endonucleolytic|
|apoptotic nuclear changes|
|cellular component disassembly involved in execution phase of apoptosis|
|endoribonuclease activity|
|DNA catabolic process|
|positive regulation of response to drug|
|regulation of response to reactive oxygen species|
|regulation of cellular response to drug|
|endonuclease activity|
|regulation of execution phase of apoptosis|
|neuron death|
|execution phase of apoptosis|
|regulation of oxidative stress-induced cell death|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|regulation of cellular response to oxidative stress|
|cellular response to carbohydrate stimulus|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|cellular response to calcium ion|
|regulation of response to oxidative stress|
|cellular glucose homeostasis|
|regulation of response to drug|
|perikaryon|
|response to estradiol|
|response to glucose|
|response to hexose|
|response to monosaccharide|
|response to calcium ion|
|RNA phosphodiester bond hydrolysis|
|response to carbohydrate|
|glucose homeostasis|
|carbohydrate homeostasis|
|cellular response to hypoxia|
|cellular response to metal ion|
|positive regulation of DNA metabolic process|
|nucleic acid binding|
|cellular response to decreased oxygen levels|
|response to mechanical stimulus|
|cellular response to oxygen levels|
|cellular response to inorganic substance|
|DNA recombination|
|cellular response to oxidative stress|
|response to tumor necrosis factor|
|aging|
|nucleic acid phosphodiester bond hydrolysis|
|response to antibiotic|
|response to hypoxia|
|regulation of DNA metabolic process|
|response to decreased oxygen levels|
|positive regulation of cellular catabolic process|
|response to metal ion|
|nucleobase-containing compound catabolic process|
|in utero embryonic development|
|response to oxygen levels|
|response to oxidative stress|
|mitochondrial inner membrane|
|cellular component disassembly|
|positive regulation of catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|response to inorganic substance|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|positive regulation of cell death|
|regulation of cellular response to stress|
|cellular chemical homeostasis|
|DNA metabolic process|
|regulation of cellular catabolic process|
|response to lipid|
|cellular homeostasis|
|cellular macromolecule catabolic process|
|response to hormone|
|response to organic cyclic compound|
|apoptotic process|
|embryo development|
|regulation of catabolic process|
|macromolecule catabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell death|
|response to cytokine|
|chemical homeostasis|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|mitochondrion|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|homeostatic process|
|RNA metabolic process|
|regulation of cell death|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17304
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ENDOG Expression in NALM6 Cells: 3.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>