======= ENPEP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ENPEP
  * **<color #00a2e8>Official Name</color>**: glutamyl aminopeptidase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2028|2028]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q07075|Q07075]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ENPEP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ENPEP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138297|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of angiotensin levels in blood|
|angiotensin maturation|
|regulation of systemic arterial blood pressure by circulatory renin-angiotensin|
|metalloaminopeptidase activity|
|regulation of systemic arterial blood pressure by renin-angiotensin|
|aminopeptidase activity|
|peptide catabolic process|
|peptide hormone processing|
|regulation of systemic arterial blood pressure by hormone|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|endocrine process|
|brush border|
|glomerulus development|
|peptide binding|
|apical part of cell|
|regulation of systemic arterial blood pressure|
|nephron development|
|protein processing|
|regulation of blood pressure|
|hormone metabolic process|
|protein maturation|
|cytoplasmic vesicle|
|kidney development|
|renal system development|
|lysosomal membrane|
|angiogenesis|
|apical plasma membrane|
|urogenital system development|
|blood circulation|
|external side of plasma membrane|
|circulatory system process|
|blood vessel morphogenesis|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|peptide metabolic process|
|regulation of hormone levels|
|cell population proliferation|
|tube morphogenesis|
|cellular amide metabolic process|
|zinc ion binding|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cell migration|
|organonitrogen compound catabolic process|
|cell motility|
|localization of cell|
|cell-cell signaling|
|proteolysis|
|locomotion|
|integral component of plasma membrane|
|movement of cell or subcellular component|
|organic substance catabolic process|
|cellular catabolic process|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10046
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ENPEP Expression in NALM6 Cells: 2.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>