======= ENSA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ENSA
  * **<color #00a2e8>Official Name</color>**: endosulfine alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2029|2029]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43768|O43768]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ENSA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ENSA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603061|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Endosulfine|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatase inhibitor activity|
|ion channel inhibitor activity|
|potassium channel inhibitor activity|
|protein phosphatase 2A binding|
|protein phosphatase regulator activity|
|protein phosphatase inhibitor activity|
|negative regulation of phosphoprotein phosphatase activity|
|negative regulation of protein dephosphorylation|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|regulation of phosphoprotein phosphatase activity|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|response to glucose|
|regulation of protein dephosphorylation|
|response to hexose|
|response to monosaccharide|
|response to carbohydrate|
|regulation of phosphatase activity|
|regulation of insulin secretion|
|regulation of peptide hormone secretion|
|regulation of dephosphorylation|
|response to nutrient|
|regulation of hormone secretion|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|signaling receptor binding|
|negative regulation of hydrolase activity|
|regulation of protein secretion|
|cell division|
|regulation of peptide secretion|
|response to nutrient levels|
|response to extracellular stimulus|
|regulation of hormone levels|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|mitotic cell cycle|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|negative regulation of catalytic activity|
|regulation of secretion|
|cell cycle process|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|cell cycle|
|response to oxygen-containing compound|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12776
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ENSA Expression in NALM6 Cells: 6.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>