======= ENY2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ENY2
  * **<color #00a2e8>Official Name</color>**: ENY2 transcription and export complex 2 subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56943|56943]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NPA8|Q9NPA8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ENY2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ENY2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619015|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. {ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:21746879}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EnY2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DUBm complex|
|transcription export complex 2|
|negative regulation of insulin secretion involved in cellular response to glucose stimulus|
|nuclear pore nuclear basket|
|SAGA complex|
|poly(A)+ mRNA export from nucleus|
|histone deubiquitination|
|negative regulation of insulin secretion|
|negative regulation of peptide hormone secretion|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|negative regulation of hormone secretion|
|nuclear receptor transcription coactivator activity|
|transcription elongation from RNA polymerase II promoter|
|DNA-templated transcription, elongation|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|regulation of insulin secretion|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|negative regulation of secretion by cell|
|regulation of peptide hormone secretion|
|RNA localization|
|negative regulation of secretion|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|regulation of hormone secretion|
|protein deubiquitination|
|transcription coactivator activity|
|protein modification by small protein removal|
|histone modification|
|covalent chromatin modification|
|chromatin binding|
|regulation of protein secretion|
|transcription by RNA polymerase II|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of hormone levels|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|chromatin organization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of cellular localization|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|regulation of protein localization|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|proteolysis|
|organic cyclic compound biosynthetic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|protein transport|
|intracellular transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-2.55|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-2.32|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-2.19|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.98|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.86|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.83|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-1.82|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.81|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.77|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.74|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.71|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.7|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.7|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.71|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.75|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.77|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.79|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.8|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.83|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.89|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.94|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.96|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.02|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.06|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|2.13|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.16|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.2|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|2.22|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.31|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.34|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.37|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.42|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.45|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.47|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.52|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.52|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.58|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.7|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.75|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.76|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.79|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.99|
|[[:results:exp211|AICAR 240μM R05 exp211]]|3|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|3.05|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|3.06|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|3.11|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|3.11|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|3.15|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|3.17|
|[[:results:exp135|MS023 7μM R03 exp135]]|3.21|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|3.21|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|3.31|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|3.45|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|3.56|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|3.57|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|3.58|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|3.62|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|3.95|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|4.72|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|6.31|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|6.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nxt1|NXT1]]|0.642|
|[[:human genes:g:gfpt1|GFPT1]]|0.623|
|[[:human genes:r:rptor|RPTOR]]|0.623|
|[[:human genes:h:hars|HARS]]|0.622|
|[[:human genes:h:hspd1|HSPD1]]|0.618|
|[[:human genes:p:pmm2|PMM2]]|0.603|
|[[:human genes:g:gmppb|GMPPB]]|0.603|
|[[:human genes:d:dpagt1|DPAGT1]]|0.602|
|[[:human genes:c:casp9|CASP9]]|0.593|
|[[:human genes:p:plaa|PLAA]]|0.586|
|[[:human genes:a:apaf1|APAF1]]|0.584|
|[[:human genes:m:meaf6|MEAF6]]|0.584|
|[[:human genes:t:thg1l|THG1L]]|0.583|
|[[:human genes:c:csnk2b|CSNK2B]]|0.579|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.578|
|[[:human genes:u:uap1|UAP1]]|0.572|
|[[:human genes:a:alg5|ALG5]]|0.57|
|[[:human genes:h:hccs|HCCS]]|0.568|
|[[:human genes:t:triap1|TRIAP1]]|0.564|
|[[:human genes:a:alg1|ALG1]]|0.558|
|[[:human genes:r:rnmt|RNMT]]|0.557|
|[[:human genes:a:atp5j|ATP5J]]|0.556|
|[[:human genes:c:cycs|CYCS]]|0.554|
|[[:human genes:u:ubqln1|UBQLN1]]|0.553|
|[[:human genes:b:bap1|BAP1]]|0.542|
|[[:human genes:d:dohh|DOHH]]|0.539|
|[[:human genes:b:bak1|BAK1]]|0.539|
|[[:human genes:n:nupl2|NUPL2]]|0.535|
|[[:human genes:r:rtcb|RTCB]]|0.534|
|[[:human genes:f:faf2|FAF2]]|0.526|
|[[:human genes:u:ube2g2|UBE2G2]]|0.524|
|[[:human genes:a:adsl|ADSL]]|0.523|
|[[:human genes:u:utp23|UTP23]]|0.523|
|[[:human genes:w:wdr24|WDR24]]|0.52|
|[[:human genes:t:thoc6|THOC6]]|0.518|
|[[:human genes:a:atxn10|ATXN10]]|0.514|
|[[:human genes:m:march5|MARCH5]]|0.513|
|[[:human genes:u:ube2k|UBE2K]]|0.51|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.506|
|[[:human genes:d:diablo|DIABLO]]|0.505|
|[[:human genes:m:mtor|MTOR]]|0.504|
|[[:human genes:a:alg2|ALG2]]|0.503|
|[[:human genes:g:gabpa|GABPA]]|0.503|
|[[:human genes:d:dnajc3|DNAJC3]]|0.502|
|[[:human genes:v:vhl|VHL]]|0.502|
|[[:human genes:g:gtf3a|GTF3A]]|0.5|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.498|
|[[:human genes:e:eif4e|EIF4E]]|0.495|
|[[:human genes:m:mfn1|MFN1]]|0.495|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.493|
|[[:human genes:t:tgs1|TGS1]]|0.485|
|[[:human genes:u:uba3|UBA3]]|0.484|
|[[:human genes:s:srp14|SRP14]]|0.484|
|[[:human genes:u:uhrf1|UHRF1]]|0.483|
|[[:human genes:v:vdac2|VDAC2]]|0.483|
|[[:human genes:m:mapk14|MAPK14]]|0.481|
|[[:human genes:t:trmt5|TRMT5]]|0.48|
|[[:human genes:u:ube2j1|UBE2J1]]|0.479|
|[[:human genes:p:pelo|PELO]]|0.479|
|[[:human genes:r:rpe|RPE]]|0.478|
|[[:human genes:a:atp5o|ATP5O]]|0.476|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.475|
|[[:human genes:k:kdsr|KDSR]]|0.475|
|[[:human genes:n:nae1|NAE1]]|0.474|
|[[:human genes:d:dpf2|DPF2]]|0.474|
|[[:human genes:c:ccdc101|CCDC101]]|0.473|
|[[:human genes:s:serf2|SERF2]]|0.472|
|[[:human genes:a:atp5b|ATP5B]]|0.471|
|[[:human genes:a:atp5i|ATP5I]]|0.471|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.47|
|[[:human genes:t:tbp|TBP]]|0.469|
|[[:human genes:s:ssb|SSB]]|0.469|
|[[:human genes:t:tle4|TLE4]]|0.469|
|[[:human genes:d:dad1|DAD1]]|0.468|
|[[:human genes:d:derl2|DERL2]]|0.468|
|[[:human genes:t:tmed10|TMED10]]|0.468|
|[[:human genes:w:wdr59|WDR59]]|0.466|
|[[:human genes:s:sdha|SDHA]]|0.465|
|[[:human genes:e:eprs|EPRS]]|0.463|
|[[:human genes:a:alg6|ALG6]]|0.462|
|[[:human genes:d:dhps|DHPS]]|0.461|
|[[:human genes:k:kctd5|KCTD5]]|0.461|
|[[:human genes:c:cct7|CCT7]]|0.46|
|[[:human genes:t:thoc3|THOC3]]|0.458|
|[[:human genes:v:vezt|VEZT]]|0.458|
|[[:human genes:d:ddhd2|DDHD2]]|0.457|
|[[:human genes:m:med16|MED16]]|0.455|
|[[:human genes:r:romo1|ROMO1]]|0.455|
|[[:human genes:a:alg13|ALG13]]|0.454|
|[[:human genes:r:rpp21|RPP21]]|0.452|
|[[:human genes:s:seh1l|SEH1L]]|0.452|
|[[:human genes:n:nars|NARS]]|0.452|
|[[:human genes:c:cbfb|CBFB]]|0.452|
|[[:human genes:s:sec16a|SEC16A]]|0.449|
|[[:human genes:a:abcf3|ABCF3]]|0.448|
|[[:human genes:p:pax5|PAX5]]|0.446|
|[[:human genes:p:pam16|PAM16]]|0.446|
|[[:human genes:i:id3|ID3]]|0.446|
|[[:human genes:m:mrps33|MRPS33]]|0.446|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.445|
|[[:human genes:d:dr1|DR1]]|0.445|
|[[:human genes:d:dolk|DOLK]]|0.444|
|[[:human genes:t:tmem41b|TMEM41B]]|0.444|
|[[:human genes:b:btaf1|BTAF1]]|0.443|
|[[:human genes:o:osgep|OSGEP]]|0.443|
|[[:human genes:a:atp5a1|ATP5A1]]|0.443|
|[[:human genes:m:manf|MANF]]|0.442|
|[[:human genes:a:aars|AARS]]|0.44|
|[[:human genes:t:txnrd1|TXNRD1]]|0.438|
|[[:human genes:e:eif3f|EIF3F]]|0.438|
|[[:human genes:n:nsd1|NSD1]]|0.438|
|[[:human genes:m:mars|MARS]]|0.438|
|[[:human genes:u:uba5|UBA5]]|0.437|
|[[:human genes:h:haus8|HAUS8]]|0.436|
|[[:human genes:a:atp5f1|ATP5F1]]|0.434|
|[[:human genes:o:oraov1|ORAOV1]]|0.434|
|[[:human genes:s:spcs2|SPCS2]]|0.434|
|[[:human genes:c:cars|CARS]]|0.433|
|[[:human genes:p:pcbp2|PCBP2]]|0.433|
|[[:human genes:s:suv420h1|SUV420H1]]|0.433|
|[[:human genes:u:uso1|USO1]]|0.43|
|[[:human genes:t:tsen54|TSEN54]]|0.429|
|[[:human genes:t:tp53|TP53]]|0.428|
|[[:human genes:d:derl1|DERL1]]|0.427|
|[[:human genes:c:crls1|CRLS1]]|0.427|
|[[:human genes:m:mbtps2|MBTPS2]]|0.427|
|[[:human genes:s:sec61g|SEC61G]]|0.426|
|[[:human genes:o:otud5|OTUD5]]|0.426|
|[[:human genes:p:ppa2|PPA2]]|0.425|
|[[:human genes:s:srp68|SRP68]]|0.424|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.424|
|[[:human genes:s:sec62|SEC62]]|0.424|
|[[:human genes:r:rad23b|RAD23B]]|0.423|
|[[:human genes:f:fbxo11|FBXO11]]|0.421|
|[[:human genes:n:nsmce1|NSMCE1]]|0.42|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.419|
|[[:human genes:m:med4|MED4]]|0.418|
|[[:human genes:a:alg14|ALG14]]|0.418|
|[[:human genes:s:slc25a26|SLC25A26]]|0.417|
|[[:human genes:t:tti2|TTI2]]|0.417|
|[[:human genes:t:tbca|TBCA]]|0.417|
|[[:human genes:g:gfer|GFER]]|0.415|
|[[:human genes:a:atp2a2|ATP2A2]]|0.414|
|[[:human genes:d:dhdds|DHDDS]]|0.414|
|[[:human genes:t:thoc7|THOC7]]|0.412|
|[[:human genes:a:alg3|ALG3]]|0.412|
|[[:human genes:n:nup50|NUP50]]|0.411|
|[[:human genes:l:lsmd1|LSMD1]]|0.411|
|[[:human genes:m:mios|MIOS]]|0.409|
|[[:human genes:t:timm13|TIMM13]]|0.408|
|[[:human genes:y:yars|YARS]]|0.408|
|[[:human genes:p:prkrir|PRKRIR]]|0.407|
|[[:human genes:s:slc35b1|SLC35B1]]|0.407|
|[[:human genes:a:atad1|ATAD1]]|0.407|
|[[:human genes:v:vrk1|VRK1]]|0.407|
|[[:human genes:d:dars2|DARS2]]|0.405|
|[[:human genes:t:tti1|TTI1]]|0.405|
|[[:human genes:m:mrps14|MRPS14]]|0.403|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.403|
|[[:human genes:u:urm1|URM1]]|0.402|
|[[:human genes:g:gemin5|GEMIN5]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3515
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ENY2 Expression in NALM6 Cells: 5.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>