======= EPB41 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EPB41
  * **<color #00a2e8>Official Name</color>**: erythrocyte membrane protein band 4.1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2035|2035]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11171|P11171]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EPB41&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EPB41|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/130500|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FERM C|
|4 1 CTD|
|SAB|
|FA|
|FERM M|
|FERM N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of protein localization to cell cortex|
|regulation of protein localization to cell cortex|
|spectrin-associated cytoskeleton|
|regulation of intestinal absorption|
|cell cortex region|
|1-phosphatidylinositol binding|
|cortical cytoskeleton|
|spectrin binding|
|phosphoprotein binding|
|regulation of digestive system process|
|cortical actin cytoskeleton organization|
|cortical cytoskeleton organization|
|cytoplasmic side of plasma membrane|
|positive regulation of protein localization to cell periphery|
|positive regulation of protein binding|
|structural constituent of cytoskeleton|
|protein N-terminus binding|
|regulation of protein localization to cell periphery|
|actomyosin structure organization|
|regulation of cell shape|
|positive regulation of binding|
|protein C-terminus binding|
|basolateral plasma membrane|
|calmodulin binding|
|regulation of protein binding|
|regulation of calcium ion transport|
|postsynaptic density|
|actin binding|
|positive regulation of cellular protein localization|
|regulation of binding|
|regulation of metal ion transport|
|regulation of cell morphogenesis|
|cell division|
|actin cytoskeleton organization|
|regulation of cellular protein localization|
|cell junction|
|actin filament-based process|
|regulation of system process|
|protein-containing complex|
|regulation of ion transport|
|regulation of cellular localization|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|cell cycle|
|protein-containing complex assembly|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.519|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11363
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EPB41 Expression in NALM6 Cells: 7.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>