======= EPB41L2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EPB41L2
  * **<color #00a2e8>Official Name</color>**: erythrocyte membrane protein band 4.1 like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2037|2037]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43491|O43491]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EPB41L2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EPB41L2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603237|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FERM M|
|FERM N|
|FERM C|
|SAB|
|4 1 CTD|
|FA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|PH domain binding|
|positive regulation of protein localization to cell cortex|
|spectrin|
|regulation of protein localization to cell cortex|
|cell cortex region|
|spectrin binding|
|COP9 signalosome|
|cortical actin cytoskeleton organization|
|cortical cytoskeleton organization|
|positive regulation of protein localization to cell periphery|
|actomyosin structure organization|
|regulation of protein localization to cell periphery|
|structural molecule activity|
|actin binding|
|positive regulation of cellular protein localization|
|focal adhesion|
|cell division|
|actin cytoskeleton organization|
|regulation of cellular protein localization|
|cell junction|
|actin filament-based process|
|regulation of cellular localization|
|regulation of protein localization|
|cytoskeleton organization|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.82|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.8|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.87|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.07|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.42|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|5.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6001
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EPB41L2 Expression in NALM6 Cells: 6.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>