======= EPHA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EPHA2
  * **<color #00a2e8>Official Name</color>**: EPH receptor A2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1969|1969]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29317|P29317]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EPHA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EPHA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176946|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand- independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:16236711, ECO:0000269|PubMed:18339848, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:27385333}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAM 2|
|Ephrin lbd|
|Pkinase Tyr|
|fn3|
|Pkinase|
|SAM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|notochord cell differentiation|
|notochord cell development|
|axial mesoderm formation|
|tight junction|
|negative regulation of lymphangiogenesis|
|axial mesoderm morphogenesis|
|positive regulation of bicellular tight junction assembly|
|notochord formation|
|regulation of lymphangiogenesis|
|lens fiber cell morphogenesis|
|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|axial mesoderm development|
|pericyte cell differentiation|
|leading edge membrane|
|notochord morphogenesis|
|mammary gland epithelial cell proliferation|
|lens fiber cell development|
|transmembrane-ephrin receptor activity|
|negative regulation of chemokine production|
|post-anal tail morphogenesis|
|notochord development|
|regulation of bicellular tight junction assembly|
|lamellipodium membrane|
|lens morphogenesis in camera-type eye|
|cAMP metabolic process|
|endothelial cell proliferation|
|branching involved in mammary gland duct morphogenesis|
|lens fiber cell differentiation|
|regulation of lamellipodium assembly|
|mammary gland duct morphogenesis|
|positive regulation of cell junction assembly|
|protein kinase B signaling|
|cyclic nucleotide metabolic process|
|regulation of lamellipodium organization|
|mammary gland morphogenesis|
|osteoclast differentiation|
|bone remodeling|
|regulation of cell adhesion mediated by integrin|
|negative regulation of protein kinase B signaling|
|transmembrane receptor protein tyrosine kinase activity|
|positive regulation of protein localization to plasma membrane|
|sprouting angiogenesis|
|mammary gland epithelium development|
|positive regulation of protein localization to cell periphery|
|mesoderm formation|
|vasculogenesis|
|mesoderm morphogenesis|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|virus receptor activity|
|lens development in camera-type eye|
|regulation of chemokine production|
|epithelial cell proliferation|
|ephrin receptor signaling pathway|
|regulation of cell junction assembly|
|regulation of blood vessel endothelial cell migration|
|defense response to Gram-positive bacterium|
|regulation of protein localization to plasma membrane|
|viral entry into host cell|
|ruffle membrane|
|activation of GTPase activity|
|gland morphogenesis|
|tissue remodeling|
|entry into host|
|negative regulation of angiogenesis|
|entry into host cell|
|negative regulation of blood vessel morphogenesis|
|formation of primary germ layer|
|myeloid leukocyte differentiation|
|camera-type eye morphogenesis|
|regulation of protein localization to cell periphery|
|negative regulation of vasculature development|
|positive regulation of protein localization to membrane|
|mesoderm development|
|osteoblast differentiation|
|mammary gland development|
|branching morphogenesis of an epithelial tube|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|eye morphogenesis|
|intrinsic apoptotic signaling pathway|
|interaction with host|
|regulation of endothelial cell migration|
|morphogenesis of a branching epithelium|
|gastrulation|
|neural tube development|
|morphogenesis of a branching structure|
|lamellipodium|
|protein localization to plasma membrane|
|regulation of protein localization to membrane|
|epithelial cell development|
|regulation of plasma membrane bounded cell projection assembly|
|viral life cycle|
|regulation of cell projection assembly|
|receptor complex|
|cell chemotaxis|
|regulation of epithelial cell migration|
|regulation of protein kinase B signaling|
|myeloid cell differentiation|
|protein localization to cell periphery|
|sensory organ morphogenesis|
|axon guidance|
|ossification|
|neuron projection guidance|
|negative regulation of cytokine production|
|keratinocyte differentiation|
|apoptotic signaling pathway|
|regulation of angiogenesis|
|embryonic organ morphogenesis|
|regulation of ERK1 and ERK2 cascade|
|epithelial tube morphogenesis|
|cadherin binding|
|purine ribonucleotide metabolic process|
|camera-type eye development|
|epidermal cell differentiation|
|angiogenesis|
|regulation of vasculature development|
|neuron projection|
|positive regulation of cellular protein localization|
|ribonucleotide metabolic process|
|defense response to bacterium|
|leukocyte differentiation|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|eye development|
|visual system development|
|sensory system development|
|purine-containing compound metabolic process|
|axonogenesis|
|skin development|
|blood vessel morphogenesis|
|axon development|
|gland development|
|positive regulation of GTPase activity|
|epidermis development|
|focal adhesion|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|neuron projection morphogenesis|
|protein localization to membrane|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|cell projection morphogenesis|
|skeletal system development|
|inflammatory response|
|negative regulation of intracellular signal transduction|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|cell part morphogenesis|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|response to growth factor|
|regulation of cellular protein localization|
|nucleobase-containing small molecule metabolic process|
|sensory organ development|
|chemotaxis|
|taxis|
|cell population proliferation|
|hemopoiesis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|hematopoietic or lymphoid organ development|
|cell surface|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|neuron projection development|
|regulation of cell adhesion|
|epithelial cell differentiation|
|response to bacterium|
|regulation of cytokine production|
|regulation of plasma membrane bounded cell projection organization|
|viral process|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|symbiotic process|
|neuron development|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|peptidyl-amino acid modification|
|organophosphate metabolic process|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|regulation of cellular localization|
|apoptotic process|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|defense response to other organism|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|protein phosphorylation|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|cell death|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|ATP binding|
|generation of neurons|
|movement of cell or subcellular component|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|cellular response to stress|
|small molecule metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14551
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EPHA2 Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>