======= EPHA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EPHA3
  * **<color #00a2e8>Official Name</color>**: EPH receptor A3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2042|2042]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29320|P29320]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EPHA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EPHA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179611|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. {ECO:0000269|PubMed:11870224}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|SAM 2|
|Ephrin lbd|
|Pkinase|
|GCC2 GCC3|
|fn3|
|SAM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fasciculation of motor neuron axon|
|fasciculation of sensory neuron axon|
|GPI-linked ephrin receptor activity|
|transmembrane-ephrin receptor activity|
|neuron projection fasciculation|
|axonal fasciculation|
|negative regulation of endocytosis|
|neuron recognition|
|positive regulation of protein localization to plasma membrane|
|transmembrane receptor protein tyrosine kinase activity|
|regulation of cell-substrate junction assembly|
|regulation of focal adhesion assembly|
|positive regulation of protein localization to cell periphery|
|regulation of adherens junction organization|
|cellular response to retinoic acid|
|regulation of epithelial to mesenchymal transition|
|ephrin receptor signaling pathway|
|regulation of cell junction assembly|
|regulation of protein localization to plasma membrane|
|response to retinoic acid|
|regulation of cell-matrix adhesion|
|regulation of protein localization to cell periphery|
|positive regulation of protein localization to membrane|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|regulation of protein localization to membrane|
|regulation of microtubule cytoskeleton organization|
|receptor complex|
|regulation of endocytosis|
|cellular response to acid chemical|
|regulation of cell-substrate adhesion|
|regulation of microtubule-based process|
|cell recognition|
|early endosome|
|axon guidance|
|neuron projection guidance|
|positive regulation of neuron projection development|
|neuron projection|
|positive regulation of cellular protein localization|
|regulation of actin cytoskeleton organization|
|response to acid chemical|
|positive regulation of neuron differentiation|
|axonogenesis|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|negative regulation of transport|
|cell projection morphogenesis|
|regulation of neuron projection development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|cellular response to lipid|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|regulation of vesicle-mediated transport|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|response to lipid|
|peptidyl-amino acid modification|
|regulation of cellular localization|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|neuron differentiation|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|localization of cell|
|cell motility|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|positive regulation of developmental process|
|integral component of plasma membrane|
|ATP binding|
|generation of neurons|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.557|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16853
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EPHA3 Expression in NALM6 Cells: -1.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>