======= EPHX2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EPHX2
  * **<color #00a2e8>Official Name</color>**: epoxide hydrolase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2053|2053]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P34913|P34913]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EPHX2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EPHX2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/132811|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Abhydrolase 6|
|Hydrolase|
|Abhydrolase 5|
|Hydrolase 4|
|Abhydrolase 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity|
|stilbene catabolic process|
|stilbene metabolic process|
|olefin metabolic process|
|epoxide metabolic process|
|epoxide hydrolase activity|
|toxic substance binding|
|lipid phosphatase activity|
|ether metabolic process|
|epoxygenase P450 pathway|
|long-chain fatty acid biosynthetic process|
|phospholipid dephosphorylation|
|phosphatase activity|
|peroxisomal matrix|
|regulation of cholesterol metabolic process|
|positive regulation of blood vessel diameter|
|arachidonic acid metabolic process|
|establishment of protein localization to peroxisome|
|protein targeting to peroxisome|
|protein localization to peroxisome|
|peroxisomal transport|
|cholesterol homeostasis|
|peroxisome organization|
|sterol homeostasis|
|unsaturated fatty acid metabolic process|
|peroxisome|
|icosanoid metabolic process|
|reactive oxygen species metabolic process|
|regulation of steroid metabolic process|
|long-chain fatty acid metabolic process|
|fatty acid biosynthetic process|
|xenobiotic metabolic process|
|lipid homeostasis|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|fatty acid derivative metabolic process|
|vascular process in circulatory system|
|regulation of blood pressure|
|monocarboxylic acid biosynthetic process|
|cellular response to xenobiotic stimulus|
|lipid modification|
|magnesium ion binding|
|response to xenobiotic stimulus|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|dephosphorylation|
|fatty acid metabolic process|
|protein targeting|
|blood circulation|
|regulation of lipid metabolic process|
|circulatory system process|
|regulation of small molecule metabolic process|
|establishment of protein localization to organelle|
|cellular calcium ion homeostasis|
|aromatic compound catabolic process|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|organic cyclic compound catabolic process|
|divalent inorganic cation homeostasis|
|inflammatory response|
|drug metabolic process|
|response to toxic substance|
|regulation of anatomical structure size|
|monocarboxylic acid metabolic process|
|cellular metal ion homeostasis|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|protein localization to organelle|
|cellular chemical homeostasis|
|ion homeostasis|
|protein homodimerization activity|
|cellular homeostasis|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|intracellular protein transport|
|oxoacid metabolic process|
|organic acid metabolic process|
|chemical homeostasis|
|lipid metabolic process|
|defense response|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp495|IWR1 50μM R08 exp495]]|-1.9|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.79|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.78|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.72|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.71|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.7|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.75|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6071
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EPHX2 Expression in NALM6 Cells: 0.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>