======= EPPIN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EPPIN
  * **<color #00a2e8>Official Name</color>**: epididymal peptidase inhibitor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57119|57119]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95925|O95925]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EPPIN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EPPIN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609031|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility. {ECO:0000269|PubMed:15229136, ECO:0000269|PubMed:17644992}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WAP|
|Kunitz BPTI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cilium-dependent cell motility|
|sperm plasma membrane|
|negative regulation of flagellated sperm motility|
|negative regulation of calcium ion import|
|regulation of flagellated sperm motility|
|regulation of cilium-dependent cell motility|
|regulation of calcium ion import|
|negative regulation of reproductive process|
|negative regulation of calcium ion transport|
|serine-type endopeptidase inhibitor activity|
|antimicrobial humoral response|
|negative regulation of ion transport|
|regulation of reproductive process|
|negative regulation of endopeptidase activity|
|regulation of calcium ion transport|
|negative regulation of peptidase activity|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|defense response to bacterium|
|humoral immune response|
|negative regulation of proteolysis|
|regulation of metal ion transport|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|negative regulation of transport|
|protein complex oligomerization|
|protein-containing complex|
|cell surface|
|response to bacterium|
|regulation of ion transport|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|regulation of cell motility|
|defense response to other organism|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|protein-containing complex assembly|
|extracellular space|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.79|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|1.94|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17452
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EPPIN Expression in NALM6 Cells: 3.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>