======= EPRS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EPRS1
  * **<color #00a2e8>Official Name</color>**: glutamyl-prolyl-tRNA synthetase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2058|2058]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07814|P07814]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EPRS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EPRS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138295|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WHEP-TRS|
|tRNA-synt 2b|
|tRNA-synt 1c|
|tRNA-synt 1c C|
|ProRS-C 1|
|HGTP anticodon|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proline-tRNA ligase activity|
|prolyl-tRNA aminoacylation|
|glutamate-tRNA ligase activity|
|glutamyl-tRNA aminoacylation|
|GAIT complex|
|regulation of long-chain fatty acid import into cell|
|long-chain fatty acid import into cell|
|lipid import into cell|
|aminoacyl-tRNA synthetase multienzyme complex|
|RNA stem-loop binding|
|regulation of fatty acid transport|
|GTPase binding|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|regulation of organic acid transport|
|long-chain fatty acid transport|
|fatty acid transport|
|regulation of anion transport|
|regulation of lipid transport|
|negative regulation of translation|
|monocarboxylic acid transport|
|regulation of lipid localization|
|negative regulation of cellular amide metabolic process|
|ribonucleoprotein complex|
|cellular response to interferon-gamma|
|cellular response to insulin stimulus|
|response to interferon-gamma|
|tRNA metabolic process|
|response to insulin|
|cellular response to peptide hormone stimulus|
|organic acid transport|
|carboxylic acid transport|
|lipid transport|
|cellular amino acid metabolic process|
|lipid localization|
|cellular response to peptide|
|regulation of translation|
|translation|
|response to peptide hormone|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|organic anion transport|
|response to peptide|
|ncRNA metabolic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|anion transport|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|import into cell|
|regulation of ion transport|
|innate immune response|
|cellular amide metabolic process|
|zinc ion binding|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|response to hormone|
|defense response to other organism|
|response to organonitrogen compound|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|organic acid metabolic process|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to nitrogen compound|
|response to cytokine|
|negative regulation of protein metabolic process|
|cellular response to endogenous stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|ion transport|
|negative regulation of cellular macromolecule biosynthetic process|
|organonitrogen compound biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.96|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.85|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.78|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.74|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-1.71|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.74|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.78|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.78|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.79|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.79|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.82|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.85|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|2.03|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.05|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.17|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.18|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.28|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.86|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|2.95|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|3.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gmppb|GMPPB]]|0.609|
|[[:human genes:r:rnmt|RNMT]]|0.565|
|[[:human genes:p:pmm2|PMM2]]|0.553|
|[[:human genes:h:hars|HARS]]|0.551|
|[[:human genes:s:spcs2|SPCS2]]|0.543|
|[[:human genes:m:mars|MARS]]|0.529|
|[[:human genes:r:rptor|RPTOR]]|0.526|
|[[:human genes:a:adsl|ADSL]]|0.523|
|[[:human genes:t:tti2|TTI2]]|0.522|
|[[:human genes:d:dpagt1|DPAGT1]]|0.522|
|[[:human genes:o:osgep|OSGEP]]|0.522|
|[[:human genes:r:rtcb|RTCB]]|0.52|
|[[:human genes:r:rpp21|RPP21]]|0.52|
|[[:human genes:a:aars|AARS]]|0.514|
|[[:human genes:n:nars|NARS]]|0.51|
|[[:human genes:d:dctn6|DCTN6]]|0.51|
|[[:human genes:t:tti1|TTI1]]|0.509|
|[[:human genes:t:thg1l|THG1L]]|0.508|
|[[:human genes:n:nae1|NAE1]]|0.507|
|[[:human genes:p:pelo|PELO]]|0.5|
|[[:human genes:a:alg2|ALG2]]|0.498|
|[[:human genes:g:gnb1l|GNB1L]]|0.498|
|[[:human genes:d:ddost|DDOST]]|0.496|
|[[:human genes:a:alg14|ALG14]]|0.496|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.495|
|[[:human genes:t:tsen2|TSEN2]]|0.494|
|[[:human genes:p:pam16|PAM16]]|0.493|
|[[:human genes:c:csnk2b|CSNK2B]]|0.492|
|[[:human genes:v:vrk1|VRK1]]|0.492|
|[[:human genes:t:tbca|TBCA]]|0.49|
|[[:human genes:e:exoc4|EXOC4]]|0.489|
|[[:human genes:s:snf8|SNF8]]|0.487|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.484|
|[[:human genes:e:exoc3|EXOC3]]|0.483|
|[[:human genes:a:alg1|ALG1]]|0.482|
|[[:human genes:m:med16|MED16]]|0.481|
|[[:human genes:s:srp14|SRP14]]|0.479|
|[[:human genes:c:ccdc101|CCDC101]]|0.477|
|[[:human genes:a:atxn10|ATXN10]]|0.476|
|[[:human genes:c:cct7|CCT7]]|0.475|
|[[:human genes:d:ddx20|DDX20]]|0.475|
|[[:human genes:d:dad1|DAD1]]|0.472|
|[[:human genes:d:dhps|DHPS]]|0.472|
|[[:human genes:s:seh1l|SEH1L]]|0.466|
|[[:human genes:y:yars|YARS]]|0.464|
|[[:human genes:t:tbcd|TBCD]]|0.464|
|[[:human genes:e:eny2|ENY2]]|0.463|
|[[:human genes:h:hspd1|HSPD1]]|0.463|
|[[:human genes:u:uxt|UXT]]|0.458|
|[[:human genes:r:rpe|RPE]]|0.458|
|[[:human genes:r:rpn1|RPN1]]|0.457|
|[[:human genes:e:eif4e|EIF4E]]|0.456|
|[[:human genes:g:gemin8|GEMIN8]]|0.454|
|[[:human genes:m:med4|MED4]]|0.454|
|[[:human genes:p:pax5|PAX5]]|0.453|
|[[:human genes:m:mtor|MTOR]]|0.452|
|[[:human genes:u:uap1|UAP1]]|0.45|
|[[:human genes:u:uhrf1|UHRF1]]|0.45|
|[[:human genes:g:gfpt1|GFPT1]]|0.45|
|[[:human genes:i:iars2|IARS2]]|0.448|
|[[:human genes:g:gemin5|GEMIN5]]|0.448|
|[[:human genes:r:rbm14|RBM14]]|0.448|
|[[:human genes:c:cep350|CEP350]]|0.444|
|[[:human genes:t:triap1|TRIAP1]]|0.443|
|[[:human genes:a:alg13|ALG13]]|0.442|
|[[:human genes:t:thoc3|THOC3]]|0.441|
|[[:human genes:t:telo2|TELO2]]|0.44|
|[[:human genes:u:utp23|UTP23]]|0.438|
|[[:human genes:n:nsmce1|NSMCE1]]|0.435|
|[[:human genes:d:dohh|DOHH]]|0.432|
|[[:human genes:r:rabggtb|RABGGTB]]|0.431|
|[[:human genes:w:wdr24|WDR24]]|0.431|
|[[:human genes:c:cars|CARS]]|0.431|
|[[:human genes:v:vezt|VEZT]]|0.43|
|[[:human genes:g:gemin6|GEMIN6]]|0.428|
|[[:human genes:t:tprkb|TPRKB]]|0.425|
|[[:human genes:p:pisd|PISD]]|0.425|
|[[:human genes:t:trmt5|TRMT5]]|0.424|
|[[:human genes:t:timm13|TIMM13]]|0.424|
|[[:human genes:c:cep57|CEP57]]|0.423|
|[[:human genes:p:polr3h|POLR3H]]|0.422|
|[[:human genes:z:znf259|ZNF259]]|0.42|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.413|
|[[:human genes:t:tsen54|TSEN54]]|0.413|
|[[:human genes:e:eif3f|EIF3F]]|0.413|
|[[:human genes:t:tsen34|TSEN34]]|0.407|
|[[:human genes:h:haus8|HAUS8]]|0.406|
|[[:human genes:s:srp68|SRP68]]|0.405|
|[[:human genes:p:polr3b|POLR3B]]|0.404|
|[[:human genes:q:qars|QARS]]|0.403|
|[[:human genes:a:actr10|ACTR10]]|0.403|
|[[:human genes:p:ppp4c|PPP4C]]|0.402|
|[[:human genes:m:mllt1|MLLT1]]|0.401|
|[[:human genes:b:bap1|BAP1]]|0.401|
|[[:human genes:s:snapc5|SNAPC5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 651/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|23/28|
|bone|24/26|
|breast|27/33|
|central nervous system|50/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|16/21|
|liver|17/20|
|lung|65/75|
|lymphocyte|10/16|
|ovary|25/26|
|pancreas|22/24|
|peripheral nervous system|16/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|19/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|27/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 896
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EPRS Expression in NALM6 Cells: 8.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>