======= ERAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ERAP1
  * **<color #00a2e8>Official Name</color>**: endoplasmic reticulum aminopeptidase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51752|51752]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZ08|Q9NZ08]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ERAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ERAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606832|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. {ECO:0000269|PubMed:15908954, ECO:0000269|PubMed:16286653, ECO:0000269|PubMed:21478864}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-1, type II receptor binding|
|interleukin-6 receptor binding|
|metalloexopeptidase activity|
|antigen processing and presentation of endogenous peptide antigen via MHC class I|
|antigen processing and presentation of endogenous peptide antigen|
|antigen processing and presentation of endogenous antigen|
|membrane protein ectodomain proteolysis|
|metalloaminopeptidase activity|
|aminopeptidase activity|
|peptide catabolic process|
|membrane protein proteolysis|
|peptide binding|
|antigen processing and presentation of peptide antigen via MHC class I|
|fat cell differentiation|
|positive regulation of angiogenesis|
|regulation of blood pressure|
|positive regulation of vasculature development|
|antigen processing and presentation of peptide antigen|
|antigen processing and presentation|
|regulation of angiogenesis|
|endoplasmic reticulum lumen|
|angiogenesis|
|regulation of vasculature development|
|blood circulation|
|circulatory system process|
|blood vessel morphogenesis|
|regulation of innate immune response|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|regulation of response to biotic stimulus|
|peptide metabolic process|
|adaptive immune response|
|tube morphogenesis|
|response to bacterium|
|regulation of defense response|
|regulation of multi-organism process|
|cellular amide metabolic process|
|zinc ion binding|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|endoplasmic reticulum membrane|
|endoplasmic reticulum|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|regulation of response to external stimulus|
|regulation of immune response|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|positive regulation of developmental process|
|regulation of response to stress|
|extracellular space|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|cellular catabolic process|
|immune response|
|extracellular region|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.91|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.85|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-1.81|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.74|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.7|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.73|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.94|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.96|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17353
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ERAP1 Expression in NALM6 Cells: 7.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>