======= ERBB2IP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ERBIN
  * **<color #00a2e8>Official Name</color>**: erbb2 interacting protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55914|55914]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96RT1|Q96RT1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ERBB2IP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ERBB2IP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606944|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDZ|
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|basal protein localization|
|negative regulation of nucleotide-binding oligomerization domain containing signaling pathway|
|negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|
|ErbB-2 class receptor binding|
|negative regulation of monocyte chemotactic protein-1 production|
|regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|
|hemidesmosome|
|regulation of nucleotide-binding oligomerization domain containing signaling pathway|
|regulation of monocyte chemotactic protein-1 production|
|negative regulation of chemokine production|
|response to muramyl dipeptide|
|ERBB2 signaling pathway|
|basal plasma membrane|
|establishment or maintenance of epithelial cell apical/basal polarity|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|intermediate filament cytoskeleton organization|
|establishment or maintenance of apical/basal cell polarity|
|establishment or maintenance of bipolar cell polarity|
|epidermal growth factor receptor signaling pathway|
|intermediate filament-based process|
|ERBB signaling pathway|
|regulation of chemokine production|
|negative regulation of NF-kappaB transcription factor activity|
|postsynapse|
|basement membrane|
|integrin-mediated signaling pathway|
|structural constituent of cytoskeleton|
|negative regulation of DNA-binding transcription factor activity|
|establishment or maintenance of cell polarity|
|basolateral plasma membrane|
|nuclear membrane|
|cellular response to tumor necrosis factor|
|response to tumor necrosis factor|
|negative regulation of cytokine production|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|signaling receptor binding|
|glutamatergic synapse|
|protein targeting|
|nuclear speck|
|regulation of DNA-binding transcription factor activity|
|negative regulation of immune system process|
|regulation of innate immune response|
|response to peptide|
|negative regulation of intracellular signal transduction|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of response to biotic stimulus|
|cell junction|
|response to bacterium|
|regulation of cytokine production|
|enzyme linked receptor protein signaling pathway|
|regulation of defense response|
|regulation of multi-organism process|
|response to lipid|
|cell adhesion|
|biological adhesion|
|intracellular protein transport|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|response to drug|
|response to nitrogen compound|
|regulation of response to external stimulus|
|response to cytokine|
|cytoskeleton organization|
|negative regulation of molecular function|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.96|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.81|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.78|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|1.76|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.89|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.94|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12288
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ERBB2IP Expression in NALM6 Cells: 6.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>