======= ERC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ERC2
  * **<color #00a2e8>Official Name</color>**: ELKS/RAB6-interacting/CAST family member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26059|26059]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15083|O15083]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ERC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ERC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617250|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cast|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|structural constituent of presynaptic active zone|
|maintenance of presynaptic active zone structure|
|presynaptic active zone organization|
|presynaptic active zone cytoplasmic component|
|maintenance of synapse structure|
|synaptic vesicle priming|
|presynaptic active zone|
|cellular component maintenance|
|synaptic vesicle exocytosis|
|GABA-ergic synapse|
|exocytic process|
|presynaptic membrane|
|neurotransmitter secretion|
|signal release from synapse|
|synaptic vesicle cycle|
|growth cone|
|vesicle-mediated transport in synapse|
|signal release|
|neurotransmitter transport|
|synapse organization|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|cytoskeleton|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|synaptic signaling|
|cell junction|
|regulated exocytosis|
|exocytosis|
|cellular protein-containing complex assembly|
|secretion by cell|
|export from cell|
|cell-cell signaling|
|secretion|
|protein-containing complex assembly|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.75|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.96|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11586
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ERC2 Expression in NALM6 Cells: -1.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>