======= ERCC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ERCC1
  * **<color #00a2e8>Official Name</color>**: ERCC excision repair 1, endonuclease non-catalytic subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2067|2067]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07992|P07992]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ERCC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ERCC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/126380|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform 1: Non-catalytic component of a structure- specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rad10|
|HHH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of t-circle formation|
|3 overhang single-stranded DNA endodeoxyribonuclease activity|
|telomeric DNA-containing double minutes formation|
|regulation of protection from non-homologous end joining at telomere|
|negative regulation of protection from non-homologous end joining at telomere|
|meiotic mismatch repair|
|post-embryonic hemopoiesis|
|nucleotide-excision repair factor 1 complex|
|pyrimidine dimer repair by nucleotide-excision repair|
|negative regulation of telomere maintenance in response to DNA damage|
|regulation of telomere maintenance in response to DNA damage|
|ERCC4-ERCC1 complex|
|replicative cell aging|
|nucleotide-excision repair complex|
|response to disaccharide|
|response to sucrose|
|negative regulation of telomere capping|
|regulation of t-circle formation|
|single-stranded DNA endodeoxyribonuclease activity|
|pyrimidine dimer repair|
|telomere maintenance via telomere trimming|
|formation of extrachromosomal circular DNA|
|t-circle formation|
|TFIID-class transcription factor complex binding|
|telomere maintenance via recombination|
|UV protection|
|UV-damage excision repair|
|post-embryonic animal organ development|
|mitotic recombination|
|somatic recombination of immunoglobulin genes involved in immune response|
|isotype switching|
|somatic diversification of immunoglobulins involved in immune response|
|nucleotide-excision repair, preincision complex stabilization|
|nucleotide-excision repair, DNA incision, 3-to lesion|
|somatic recombination of immunoglobulin gene segments|
|global genome nucleotide-excision repair|
|regulation of telomere capping|
|immunoglobulin production involved in immunoglobulin mediated immune response|
|response to immobilization stress|
|response to X-ray|
|mismatch repair|
|multicellular organism aging|
|somatic diversification of immune receptors via germline recombination within a single locus|
|somatic cell DNA recombination|
|somatic diversification of immunoglobulins|
|nucleotide-excision repair, DNA incision, 5-to lesion|
|negative regulation of telomere maintenance|
|syncytium formation|
|transcription factor TFIID complex|
|nucleotide-excision repair, DNA incision|
|B cell activation involved in immune response|
|somatic diversification of immune receptors|
|positive regulation of telomere maintenance|
|interstrand cross-link repair|
|damaged DNA binding|
|double-strand break repair via nonhomologous end joining|
|cell aging|
|non-recombinational repair|
|response to cadmium ion|
|transcription-coupled nucleotide-excision repair|
|oogenesis|
|negative regulation of response to DNA damage stimulus|
|regulation of telomere maintenance|
|multicellular organism growth|
|cellular response to UV|
|post-embryonic development|
|telomere maintenance|
|telomere organization|
|single-stranded DNA binding|
|nuclear chromosome, telomeric region|
|lymphocyte activation involved in immune response|
|nucleotide-excision repair|
|meiosis I cell cycle process|
|cellular response to light stimulus|
|negative regulation of DNA metabolic process|
|female gamete generation|
|negative regulation of chromosome organization|
|male gonad development|
|development of primary male sexual characteristics|
|response to UV|
|response to ionizing radiation|
|B cell activation|
|male sex differentiation|
|immunoglobulin production|
|meiotic cell cycle process|
|response to carbohydrate|
|cellular response to radiation|
|positive regulation of chromosome organization|
|production of molecular mediator of immune response|
|double-strand break repair|
|protein C-terminus binding|
|positive regulation of DNA metabolic process|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|gonad development|
|response to nutrient|
|development of primary sexual characteristics|
|regulation of response to DNA damage stimulus|
|DNA recombination|
|meiotic cell cycle|
|protein domain specific binding|
|positive regulation of protein complex assembly|
|germ cell development|
|sex differentiation|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|aging|
|nucleic acid phosphodiester bond hydrolysis|
|response to light stimulus|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|anatomical structure homeostasis|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|cellular process involved in reproduction in multicellular organism|
|response to metal ion|
|negative regulation of organelle organization|
|lymphocyte activation|
|response to oxidative stress|
|developmental growth|
|growth|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|response to radiation|
|regulation of protein complex assembly|
|response to nutrient levels|
|DNA repair|
|positive regulation of cellular component biogenesis|
|response to extracellular stimulus|
|response to inorganic substance|
|spermatogenesis|
|cell population proliferation|
|hemopoiesis|
|male gamete generation|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|positive regulation of organelle organization|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|developmental process involved in reproduction|
|gamete generation|
|negative regulation of cellular component organization|
|regulation of cellular response to stress|
|DNA metabolic process|
|leukocyte mediated immunity|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|anatomical structure formation involved in morphogenesis|
|leukocyte activation|
|regulation of cellular component biogenesis|
|embryo development|
|multi-organism reproductive process|
|cell cycle process|
|chromosome organization|
|cell activation|
|immune effector process|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|regulation of response to stress|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|homeostatic process|
|cell development|
|cellular response to stress|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c17orf70|C17orf70]]|0.475|
|[[:human genes:r:rrm1|RRM1]]|0.433|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 449
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ERCC1 Expression in NALM6 Cells: 5.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>