======= ERCC4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ERCC4
  * **<color #00a2e8>Official Name</color>**: ERCC excision repair 4, endonuclease catalytic subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2072|2072]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92889|Q92889]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ERCC4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ERCC4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/133520|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link. {ECO:0000269|PubMed:19596235}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ERCC4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of double-stranded telomeric DNA binding|
|negative regulation of double-stranded telomeric DNA binding|
|nucleotide-excision repair involved in interstrand cross-link repair|
|negative regulation of telomeric DNA binding|
|regulation of protection from non-homologous end joining at telomere|
|negative regulation of protection from non-homologous end joining at telomere|
|telomeric DNA-containing double minutes formation|
|3 overhang single-stranded DNA endodeoxyribonuclease activity|
|nucleotide-excision repair factor 1 complex|
|regulation of telomere maintenance in response to DNA damage|
|negative regulation of telomere maintenance in response to DNA damage|
|ERCC4-ERCC1 complex|
|regulation of telomeric DNA binding|
|telomerase inhibitor activity|
|nucleotide-excision repair complex|
|negative regulation of telomere capping|
|endodeoxyribonuclease activity|
|single-stranded DNA endodeoxyribonuclease activity|
|TFIID-class transcription factor complex binding|
|negative regulation of telomerase activity|
|telomere maintenance via recombination|
|UV protection|
|mitotic recombination|
|resolution of meiotic recombination intermediates|
|nucleotide-excision repair, preincision complex stabilization|
|nucleotide-excision repair, DNA incision, 3-to lesion|
|meiotic chromosome separation|
|global genome nucleotide-excision repair|
|negative regulation of telomere maintenance via telomere lengthening|
|regulation of telomere capping|
|chromosome separation|
|negative regulation of telomere maintenance|
|nucleotide-excision repair, DNA incision, 5-to lesion|
|transcription factor TFIID complex|
|negative regulation of DNA biosynthetic process|
|nucleotide-excision repair, DNA incision|
|chromosome, telomeric region|
|reciprocal meiotic recombination|
|regulation of telomerase activity|
|interstrand cross-link repair|
|homologous recombination|
|negative regulation of DNA binding|
|damaged DNA binding|
|double-strand break repair via nonhomologous end joining|
|regulation of telomere maintenance via telomere lengthening|
|non-recombinational repair|
|transcription-coupled nucleotide-excision repair|
|negative regulation of response to DNA damage stimulus|
|regulation of telomere maintenance|
|cellular response to UV|
|meiotic chromosome segregation|
|double-strand break repair via homologous recombination|
|telomere maintenance|
|recombinational repair|
|telomere organization|
|protein N-terminus binding|
|single-stranded DNA binding|
|nuclear chromosome, telomeric region|
|meiosis I|
|nucleotide-excision repair|
|regulation of DNA biosynthetic process|
|meiosis I cell cycle process|
|cellular response to light stimulus|
|negative regulation of DNA metabolic process|
|regulation of DNA binding|
|negative regulation of chromosome organization|
|response to UV|
|meiotic nuclear division|
|meiotic cell cycle process|
|negative regulation of binding|
|cellular response to radiation|
|double-strand break repair|
|protein C-terminus binding|
|regulation of response to DNA damage stimulus|
|nuclear chromosome segregation|
|DNA recombination|
|meiotic cell cycle|
|positive regulation of protein complex assembly|
|chromosome segregation|
|negative regulation of transferase activity|
|nuclear division|
|nucleic acid phosphodiester bond hydrolysis|
|response to light stimulus|
|organelle fission|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|regulation of autophagy|
|anatomical structure homeostasis|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|negative regulation of organelle organization|
|regulation of binding|
|response to radiation|
|regulation of protein complex assembly|
|DNA repair|
|positive regulation of cellular component biogenesis|
|negative regulation of cellular component organization|
|regulation of cellular response to stress|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|regulation of catabolic process|
|cell cycle process|
|chromosome organization|
|identical protein binding|
|negative regulation of molecular function|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of response to stimulus|
|homeostatic process|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.32|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.89|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.87|
|[[:results:exp340|BN82002 4μM R07 exp340]]|-1.86|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.8|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.8|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1543
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ERCC4 Expression in NALM6 Cells: 4.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>